Hamad Al-Mijalli Samiah, ELsharkawy Eman R, Abdallah Emad M, Hamed Munerah, El Omari Nasreddine, Mahmud Shafi, Alshahrani Mohammed Merae, Mrabti Hanae Naceiri, Bouyahya Abdelhakim
Department of Biology, College of Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Chemistry Department, Northern Border University Saudi Arabia, Arar, Saudi Arabia.
Evid Based Complement Alternat Med. 2022 Jun 14;2022:9306251. doi: 10.1155/2022/9306251. eCollection 2022.
and are widely used in Moroccan traditional medicine for the treatment of diabetes and infectious diseases. The aims of this work were the determination of the chemical composition of (MPEO) and (LMEO) essential oils and the evaluation of their antibacterial, antioxidant, and antidiabetic activities. The chemical composition was determined by GC-MS analysis. The antibacterial effects were evaluated against several bacterial strains using disc diffusion, MIC, and MBC methods. The antioxidant activity was evaluated using DPPH, HO, and xanthine oxidase, and the antidiabetic activity was estimated by the inhibitory effects of -amylase, -glucosidase, and lipase activities. GC-MS results showed that the main compounds of MPEO were menthone (29.24%), levomenthol (38.73%), and eucalyptol (6.75%). However, eucalyptol (28.11%), 2-bornanone (11.57%), endo-borneol (7.82%), and linalyl acetate (5.22%) are the major compounds of LMEO. The results exhibited important inhibitory effects against some bacterial strains with MIC = MBC = 0.39 mg/mL for MPEO against ATCC. However, LMEO exhibited remarkable antioxidant and antidiabetic activities compared to MPEO. Indeed, LMEO inhibited DPPH, HO, and xanthine oxidase with concentrations of 15.23, 21.52, and 8.89 g/mL, respectively. Moreover, LMEO exhibited -amylase and -glucosidase at IC = 85.34 and IC = 59.36 g/mL, respectively. The findings showed that both MPEO and LMEO exhibit promising biological properties. However, the application of these species or their main bioactive compounds requires further investigation.
[植物名称1]和[植物名称2]在摩洛哥传统医学中被广泛用于治疗糖尿病和传染病。本研究的目的是确定[植物名称1]精油（MPEO）和[植物名称2]精油（LMEO）的化学成分，并评估它们的抗菌、抗氧化和抗糖尿病活性。通过气相色谱-质谱联用（GC-MS）分析确定化学成分。使用纸片扩散法、最低抑菌浓度（MIC）和最低杀菌浓度（MBC）方法评估对几种细菌菌株的抗菌效果。使用1,1-二苯基-2-苦基肼（DPPH）、羟基自由基（HO）和黄嘌呤氧化酶评估抗氧化活性，并通过α-淀粉酶、α-葡萄糖苷酶和脂肪酶活性的抑制作用估计抗糖尿病活性。GC-MS结果表明，MPEO的主要成分是薄荷酮（29.24%）、左旋薄荷醇（38.73%）和桉叶油素（6.75%）。然而，桉叶油素（28.11%）、2-冰片酮（11.57%）、内冰片醇（7.82%）和乙酸芳樟酯（5.22%）是LMEO的主要成分。结果显示，MPEO对某些细菌菌株具有重要的抑制作用，对[细菌名称]ATCC的MIC = MBC = 0.39 mg/mL。然而，与MPEO相比，LMEO表现出显著的抗氧化和抗糖尿病活性。事实上，LMEO分别以15.23、21.52和8.89 μg/mL的浓度抑制DPPH、HO和黄嘌呤氧化酶。此外，LMEO对α-淀粉酶和α-葡萄糖苷酶的半数抑制浓度（IC）分别为85.34和59.36 μg/mL。研究结果表明，MPEO和LMEO均具有良好的生物学特性。然而，这些植物或其主要生物活性化合物的应用需要进一步研究。
