Mekkaoui Mouna, Assaggaf Hamza, Qasem Ahmed, El-Shemi Adel, Abdallah Emad M, Bouidida El Houcine, Naceiri Mrabti Hanae, Cherrah Yahya, Alaoui Katim
Pharmacodynamics Research Team ERP, Laboratory of Pharmacology and Toxicology, Faculty of Medicine and Pharmacy, University Mohammed V in Rabat, Rabat BP 6203, Morocco.
Laboratory Medicine Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah 21955, Saudi Arabia.
Foods. 2021 Dec 23;11(1):28. doi: 10.3390/foods11010028.
Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical and thermal wound models in rabbits. Dressing mixtures of honey with three essential oils ( and ) were prepared and applied daily in the treatment groups. These essential oils were rich in phytochemicals and had significant antibacterial activity against four selected ATCC bacterial strains. Madecasol ointment was used as a standard control. The healing effect of the mixtures was evaluated by measuring wound surface area and comparing healing time. The results showed that the healing rate in the treatment groups was significantly higher than that of the untreated group and standard group. The best healing effect for burns was seen in the mixture of honey and essential oil, which had wound closure rates of 85.21% and 82.14% in thermal- and chemical-induced burns, respectively, and showed the shortest healing time (14 days) in comparison to other groups. Therefore, it can be concluded that honey mixtures have significant beneficial effects on skin wound healing and, thus, they may be used as a healing agent in different types of wounds in humans after specific clinical trials.
伤口愈合由几个连续的阶段组成，涉及多种细胞和化学中间体。作为丰富的营养元素来源，蜂蜜已被证明在治疗各种疾病方面具有潜在益处。本研究旨在调查一种含有特定精油的蜂蜜混合物对兔化学性和热性伤口模型的愈合效果。制备了蜂蜜与三种精油（和）的敷料混合物，并在治疗组中每日应用。这些精油富含植物化学物质，对四种选定的ATCC细菌菌株具有显著的抗菌活性。马德卡索尔软膏用作标准对照。通过测量伤口表面积和比较愈合时间来评估混合物的愈合效果。结果表明，治疗组的愈合率显著高于未治疗组和标准组。蜂蜜和精油混合物对烧伤的愈合效果最佳，在热诱导烧伤和化学诱导烧伤中，其伤口闭合率分别为85.21%和82.14%，与其他组相比愈合时间最短（14天）。因此，可以得出结论，蜂蜜混合物对皮肤伤口愈合具有显著的有益作用，因此，经过特定的临床试验后，它们可作为人类不同类型伤口的愈合剂。
