Rosendorf J, Klicova M, Herrmann I, Anthis A, Cervenkova L, Palek R, Treska V, Liska V
Department of Surgery, University Hospital in Pilsen, Pilsen, Czech Republic.
Laboratory of Cancer Treatment and Tissue Regeneration, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Front Surg. 2022 Jun 7;9:904810. doi: 10.3389/fsurg.2022.904810. eCollection 2022.
Colorectal surgery has developed rapidly in the recent decades. Nevertheless, colorectal anastomotic leakage continues to appear postoperatively in unpleasant rates and leads to life-threatening conditions. The development of valid complication-preventing methods is inefficient in many aspects as we are still lacking knowledge about the basics of the process of anastomotic wound healing in the gastrointestinal tract. Without the proper understanding of the crucial mechanisms, research for prevention of anastomotic leakage is predestined to be unsuccessful. This review article discusses known pathophysiological mechanisms together with the most lately found processes to be further studied. The aim of the article is to facilitate the orientation in the topic, support the better understanding of known mechanisms and suggest promising possibilities and directions for further research.
近几十年来，结直肠手术发展迅速。然而，结直肠吻合口漏术后仍以令人不快的发生率出现，并导致危及生命的状况。有效的并发症预防方法在许多方面发展效率低下，因为我们仍然缺乏对胃肠道吻合口伤口愈合过程基本原理的了解。如果不能正确理解关键机制，预防吻合口漏的研究注定会失败。这篇综述文章讨论了已知的病理生理机制以及有待进一步研究的最新发现的过程。本文的目的是便于在该主题上进行定位，支持对已知机制的更好理解，并为进一步研究提出有前景的可能性和方向。
