Couto Maria Eduarda, Oliveira Isabel, Domingues Nelson, Viterbo Luísa, Martins Ângelo, Moreira Ilídia, Espírito Santo Ana, Chacim Sérgio, Moreira Cláudia, Pereira Dulcineia, Henrique Rui, Mariz José
Department of Onco-Hematology, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.
Department of Pathology and Cancer Biology and Epigenetics Group - Research Centre (CI-IPOP), Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.
Indian J Hematol Blood Transfus. 2022 Jul;38(3):492-498. doi: 10.1007/s12288-021-01483-0. Epub 2021 Aug 26.
Gastric mucosa-associated lymphoid tissue non-Hodgkin lymphoma (gMALT NHL) is the second most common gastrointestinal lymphoma (50% of all gastric lymphomas), being closely associated with infection, justifying that antibiotic therapy is effective in over 75% of all cases. This is a retrospective study analyzing all adult gMALT NHL cases diagnosed and treated in a single center for 8 years, focusing on demographic features, treatment outcomes, and survival analysis. Sixty patients with a median age of 61 years (53.3% female gender) were analyzed. Most of the cases had localized disease (66.7% were Lugano stage I) and had low IPI scores (median: 1). There was a high prevalence of infection (68.3%). Nearly 97% of the cases received treatment for the disease, a median of one line; 55% of the patients treated endured complete response after first-line therapy (mostly antibiotics). Median overall survival time and median progression-free survival time were not reached. The mean follow-up time was 81.8 months (95% CI: [73.3-90.3]). Thirty-six patients (60%) achieved a 3-year follow-up time; the mortality rate was 15% at the end of the study. Age superior to 65 years and transformation into DLBCL were statistically significant negative prognostic markers for survival in this study ( = 0.006 and = 0.033, respectively). Our study confirms that gMALT NHL is an indolent disease with long-term survival. Many patients, however, are exposed to several treatment lines along their disease course.
胃黏膜相关淋巴组织非霍奇金淋巴瘤（gMALT NHL）是第二常见的胃肠道淋巴瘤（占所有胃淋巴瘤的50%），与感染密切相关，这使得抗生素治疗在超过75%的病例中有效。这是一项回顾性研究，分析了在单一中心诊断和治疗的所有成年gMALT NHL病例，为期8年，重点关注人口统计学特征、治疗结果和生存分析。分析了60例患者，中位年龄为61岁（女性占53.3%）。大多数病例为局限性疾病（66.7%为卢加诺分期I期），国际预后指数（IPI）评分较低（中位数：1）。感染患病率较高（68.3%）。近97%的病例接受了疾病治疗，中位治疗线数为1线；55%接受治疗的患者在一线治疗（主要是抗生素）后实现了完全缓解。总生存时间中位数和无进展生存时间中位数未达到。平均随访时间为81.8个月（95%CI：[73.3 - 90.3]）。36例患者（60%）达到了3年随访时间；研究结束时死亡率为15%。在本研究中，年龄大于65岁和转化为弥漫性大B细胞淋巴瘤（DLBCL）是生存的统计学显著负性预后标志物（分别为 = 0.006和 = 0.033）。我们的研究证实，gMALT NHL是一种惰性疾病，具有长期生存。然而，许多患者在其病程中接受了多种治疗方案。
