Centre for Nanoscience and Genomics, Karunya Institute of Technology and Sciences (Deemed-to-be University), Coimbatore, India.
Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed-to-be University), Coimbatore, India.
J Microencapsul. 2022 Aug;39(5):409-418. doi: 10.1080/02652048.2022.2094486. Epub 2022 Jul 7.
This study aims at tuning the properties of the nanoparticles by incorporating neodymium, exploring the sustained release of drug, and the anticancer activity on breast cancer cells. The crystal characteristics of NdCuS nanoparticles are analysed using X-ray diffraction. The morphology and size of the nanoparticles were characterised using Transmission Electron Microscope and particle size analyser. The rate of release of the encapsulated camptothecin and anticancer effects on breast cancer cells are investigated. The nanoparticles are rod-shaped, 132 ± 8 nm long and 27 ± 7 nm wide. The band gap of the nanoparticles is 4.85 eV. The drug encapsulation efficiency is 94.76% (w/w). The drug is released in a sustained manner, over a period of 180 h. The cytotoxicity of the camptothecin-loaded NPs is examined on MDA-MB-231 cells and the IC50 is 4.39 µg mL. The NdCuS nanoparticles are promising as theranostic agents considering their material characteristics and anticancer activity.
本研究旨在通过掺入钕来调整纳米粒子的性质，探索药物的持续释放和对乳腺癌细胞的抗癌活性。使用 X 射线衍射分析 NdCuS 纳米粒子的晶体特性。使用透射电子显微镜和粒度分析仪对纳米粒子的形貌和尺寸进行了表征。研究了包封喜树碱的释放速率和对乳腺癌细胞的抗癌作用。纳米粒子呈棒状，长 132±8nm，宽 27±7nm。纳米粒子的能带隙为 4.85eV。药物包封效率为 94.76%（重量/重量）。药物以持续的方式释放，持续 180 小时。载喜树碱 NPs 的细胞毒性在 MDA-MB-231 细胞上进行了检查，IC50 为 4.39µg mL。考虑到 NdCuS 纳米粒子的材料特性和抗癌活性，它们有望成为治疗诊断剂。
