Centre for Nanoscience and Genomics, Karunya Institute of Technology and Sciences (Deemed University), Coimbatore, Tamil Nadu 641114, India.
Department of Applied Chemistry, Karunya Institute of Technology and Sciences (Deemed University), Coimbatore, Tamil Nadu 641114, India.
J Biotechnol. 2024 Feb 10;381:100-108. doi: 10.1016/j.jbiotec.2023.12.017. Epub 2024 Jan 3.
Metal sulfide nanoparticles are synthesized for their biomedical applications, including cancer drug targeting. This paper reports a novel nanocomposite made of praseodymium sulfide nanoparticles and poly-cyclodextrin. The praseodymium sulfide nanoparticles were synthesized hydrothermal, autoclaving the nitrate precursors at 150 °C for 18 hours. The material is characterized using XRD and shows an orthorhombic crystal system with high crystallinity. The size and morphology of the nanomaterial were optimized. The material shows a rod-shaped morphology, as seen in the TEM image, with 150 ± 3 nm length and 25 ± 5 nm width. Particle size analysis supports this size range. The colloidal particles were stable in the aqueous medium without precipitation at neutral pH. The elements in the material in the polymer-coated form and their electronic states are studied by X-ray photoelectron spectroscopy. Thermogravimetry confirms that the material contains about 18.5% of the weight of the polymer. The material has an observable magnetic property at room temperature due to the praseodymium element. The UV-vis-NIR absorption spectrum of the material shows a long absorption range that extends to 1200 nm. The drug 5-fluorouracil is encapsulated in the nanoparticles through host: guest association, and its release profile is analyzed. The release is modulated at a slightly acidic pH, indicating the pH-tunability. The nanoparticles and 5-fluorouracil were taken in the w/w ratio of 2:1 (2/1 mg in 1 mL of deionized water). Further, the in vitro anticancer activity of the drug-encapsulated material is screened on breast cancer and non-cancerous cell lines. The IC values are reported, and the advantageous properties of the material as drug carriers are discussed.
金属硫化物纳米粒子因其在生物医学中的应用而被合成，包括癌症药物靶向。本文报道了一种由硫化镨纳米粒子和聚环糊精组成的新型纳米复合材料。硫化镨纳米粒子通过水热法合成，将硝酸盐前体在 150°C 下加热 18 小时。该材料采用 X 射线衍射进行了表征，显示出具有高结晶度的正交晶系。优化了纳米材料的尺寸和形态。TEM 图像显示，该材料呈现出棒状形态，长度为 150±3nm，宽度为 25±5nm。颗粒尺寸分析支持这个尺寸范围。在中性 pH 值下，胶体颗粒在水介质中稳定，没有沉淀。X 射线光电子能谱研究了聚合物包覆形式下的材料中的元素及其电子态。热重分析证实，该材料含有约 18.5%的聚合物重量。由于镨元素的存在，该材料在室温下具有可观察到的磁性。该材料的紫外可见近红外吸收光谱显示出一个长的吸收范围，延伸到 1200nm。通过主客体相互作用将药物 5-氟尿嘧啶包封在纳米粒子中，并分析其释放曲线。在略酸性 pH 值下，释放被调节，表明 pH 值可调。纳米粒子和 5-氟尿嘧啶的 w/w 比为 2:1（2/1mg 在 1ml 去离子水中）。此外，还在乳腺癌和非癌细胞系上筛选了载药材料的体外抗癌活性。报告了 IC 值，并讨论了该材料作为药物载体的有利特性。
