aInternal Medicine, Aging and Kidney Disease Department, University of Bologna, Bologna bDepartment of Cardiology, Istituto Auxologico Italiano, Milan, Italy.
J Hypertens. 2014 Jan;32(1):57-64. doi: 10.1097/HJH.0b013e328365b916.
Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance. The aim of our study was to verify in a large well characterized population sample the relationship between SUA values, hypertension, arterial stiffness and subclinical atherosclerosis.
For this study, we selected 248 men and 371 women adult patients enrolled in the last Brisighella Heart Study population survey for which a full set of data were available and not consuming antihypertensive, antidiabetic, lipid-lowering and uric acid-lowering drugs. SUA and other available variables were related to blood pressure level, carotid-femoral pulse wave velocity (cfPWV) and carotid intima-media thickness (cIMT).
Hypertension prevalence was strongly related to SUA quartiles: we found significant differences between the 2nd (23.0%) and the 3rd quartiles (36.4%; P vs. 2nd < 0.05), and between the 3rd and the 4th quartile (56.3%; P vs. 3rd < 0.05). Similarly, the metabolic syndrome prevalence increased significantly at 39.5% in the 3rd SUA quartile (P < 0.05 vs. 2nd) and at 58.9% in the 4th quartile (P < 0.05 vs. 3rd). Intima-media thickness gradually and significantly rose along quartiles of SUA (P for trend < 0.0001), in particular, it was 0.86 mm in the 1st quartile, 0.90 in the 2nd, 0.94 in the 3rd, and 0.97 in the last quartile, with significant differences between each quartiles (all P < 0.05). In multivariate regression analyses, SUA resulted to be significantly associated to hypertension and metabolic syndrome prevalence, and IMT. Even if a significant association between SUA and cfPWV was found in univariate analysis (P = 0.002), when adjusting for age, the trend became nonsignificant (0.20).
In the studied population sample, after adjustment for a large number of parameters, SUA appears to be significantly correlated to hypertension and IMT, but not to aortic stiffness.
血清尿酸（SUA）水平与许多公认的心血管危险因素相关，包括年龄、男性、高血压、糖尿病、高三酰甘油血症、肥胖和胰岛素抵抗。我们的研究目的是在一个大型特征明确的人群样本中验证 SUA 值与高血压、动脉僵硬和亚临床动脉粥样硬化之间的关系。
在这项研究中，我们选择了 248 名男性和 371 名女性成年患者，他们参加了 Brisighella 心脏研究的最后一次人群调查，并且有完整的数据可供使用，且未服用抗高血压、抗糖尿病、降脂和降尿酸药物。SUA 和其他可用变量与血压水平、颈动脉-股动脉脉搏波速度（cfPWV）和颈动脉内-中膜厚度（cIMT）相关。
高血压患病率与 SUA 四分位数密切相关：我们发现第 2 四分位数（23.0%）和第 3 四分位数（36.4%；P 与第 2 四分位数<0.05）以及第 3 四分位数和第 4 四分位数（56.3%；P 与第 3 四分位数<0.05）之间存在显著差异。同样，第 3 四分位数的代谢综合征患病率显著增加到 39.5%（P<0.05 与第 2 四分位数），第 4 四分位数增加到 58.9%（P<0.05 与第 3 四分位数）。沿 SUA 四分位数，内-中膜厚度逐渐显著升高（趋势 P<0.0001），特别是第 1 四分位数为 0.86mm，第 2 四分位数为 0.90mm，第 3 四分位数为 0.94mm，第 4 四分位数为 0.97mm，每个四分位数之间存在显著差异（均 P<0.05）。多元回归分析显示，SUA 与高血压和代谢综合征患病率以及 IMT 显著相关。尽管在单因素分析中发现 SUA 与 cfPWV 之间存在显著相关性（P=0.002），但在校正年龄后，这种趋势变得无统计学意义（0.20）。
在研究人群样本中，在调整了大量参数后，SUA 与高血压和 IMT 显著相关，但与主动脉僵硬不相关。
