Hou Dongsheng, Wang Xiaotong, Xia Qiuyuan, Zong Yuanyuan
Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province 250025, China.
Department of Pathology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, China.
Int J Surg Case Rep. 2022 Jul;96:107265. doi: 10.1016/j.ijscr.2022.107265. Epub 2022 May 31.
Prostate synovial sarcoma (SS) is extremely rare. We report a case of prostate SS diagnosed using fine-needle biopsy. The following findings were found: The serum prostate specific antigen level was low, magnetic resonance imaging shows an irregular soft tissue mass in the right posterior part of the prostate, and computed tomography examinations did not reveal any tumor at other parts of the body. Microscopy showed that the tumor cell morphology was densely arranged by interwoven short strands of deep-stained nuclear spindle cells. Immunohistochemical tests were positive for SS18-SSX and SSX. Molecular testing showed that SS18 break-apart Fluorescence In Situ Hybridization (FISH) results were positive, and a comprehensive analysis of this case was performed. Nine cases of prostate SS reported in the English literature were reviewed. In addition, the differential diagnosis, clinical treatment, and clinical prognosis of prostate SS are comprehensively described.
前列腺滑膜肉瘤（SS）极为罕见。我们报告一例经细针穿刺活检诊断的前列腺SS病例。发现以下情况：血清前列腺特异性抗原水平较低，磁共振成像显示前列腺右后部有一不规则软组织肿块，计算机断层扫描检查未发现身体其他部位有肿瘤。显微镜检查显示肿瘤细胞形态由交织的深染核梭形细胞短束密集排列。免疫组织化学检测SS18-SSX和SSX呈阳性。分子检测显示SS18断裂荧光原位杂交（FISH）结果为阳性，并对该病例进行了综合分析。回顾了英文文献中报道的9例前列腺SS病例。此外，还全面描述了前列腺SS的鉴别诊断、临床治疗及临床预后。
