IVFMD Phu Nhuan, My Duc Phu Nhuan Hospital, Ho Chi Minh City, Viet Nam; HOPE Research Centre, My Duc Hospital, Ho Chi Minh City, Viet Nam.
IVFMD Phu Nhuan, My Duc Phu Nhuan Hospital, Ho Chi Minh City, Viet Nam; HOPE Research Centre, My Duc Hospital, Ho Chi Minh City, Viet Nam.
Eur J Obstet Gynecol Reprod Biol. 2022 Aug;275:59-63. doi: 10.1016/j.ejogrb.2022.06.014. Epub 2022 Jun 18.
This study evaluated the effectiveness of Paraffin oil versus Mineral oil for day-5 embryo culture in couples undergoing assisted reproductive technology (ART).
We performed a multi-centre, retrospective cohort study at IVFMD (My Duc Hospital) and IVFMD Phu Nhuan (My Duc Phu Nhuan Hospital) from January 2019 to September 2019. We studied couples treated by intracytoplasmic sperm injection (ICSI), using fresh, ejaculated semen and undergoing day-5 embryo transfer. Couples who underwent in vitro maturation (IVM) or oocyte donation cycles or couples where the woman had uterine abnormalities were excluded. From January 2019 to May 2019, we used Mineral oil (LiteOil, LifeGlobal) while Paraffin oil (Liquid Paraffin, Origio) was used from June 2019 to September 2019. The primary outcome was live birth rate after the first transfer, either from a fresh transfer or frozen embryo transfer.
Between 1st January 2019 to 30th September 2019, there were 2,312 couples undergoing ART in both centres, of which 762 (377 in the Paraffin group and 385 in the Mineral group) eligible couples were included in the study. Baseline characteristics of couples were comparable between the two groups, with mean female age 31.5 ± 4.3 versus 31.9 ± 4.7 in the Paraffin and Mineral group. Live birth after the first transfer occurred in 153 (40.6%) couples in the Paraffin group, compared to 152 (39.5%) couples in the Mineral group (risk ratio 1.02, 95% confidence interval 0.91 - 1.14). Other secondary outcomes were comparable between the two groups.
In day-5 embryo culture, Paraffin and Mineral oil resulted in a comparable live birth rate.
本研究评估了在接受辅助生殖技术（ART）的夫妇中，石蜡油与矿物油用于第 5 天胚胎培养的效果。
我们于 2019 年 1 月至 9 月在 IVFMD（My Duc 医院）和 IVFMD Phu Nhuan（My Duc Phu Nhuan 医院）进行了一项多中心、回顾性队列研究。我们研究了接受胞浆内精子注射（ICSI）治疗、使用新鲜射出精液并进行第 5 天胚胎移植的夫妇。排除了接受体外成熟（IVM）或卵母细胞捐赠周期或女性子宫异常的夫妇。2019 年 1 月至 5 月，我们使用矿物油（LiteOil，LifeGlobal），2019 年 6 月至 9 月使用石蜡油（液体石蜡，Origio）。主要结局是新鲜移植或冷冻胚胎移植后的活产率。
在 2019 年 1 月 1 日至 9 月 30 日期间，两个中心共有 2312 对夫妇接受了 ART 治疗，其中 762 对（石蜡组 377 对，矿物组 385 对）符合条件的夫妇纳入研究。两组夫妇的基线特征无差异，女性平均年龄分别为 31.5±4.3 岁和 31.9±4.7 岁。石蜡组 153 对（40.6%）夫妇在第一次移植后活产，矿物组 152 对（39.5%）夫妇活产（风险比 1.02，95%置信区间 0.91-1.14）。两组的其他次要结局无差异。
在第 5 天胚胎培养中，石蜡油和矿物油的活产率无差异。
