Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu.
Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu. Correspondence to: Dr Sarala Premkumar, Associate Professor, Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu.
Indian Pediatr. 2022 Aug 15;59(8):623-625. Epub 2022 Jun 11.
To study the association between serum magnesium level and migraine in children.
This cross-sectional study enrolled children aged 5-18 years diagnosed with migraine, and age- and sex-matched controls without a headache disorder. International Classification of Headache Disorders 3 (ICHD-3) was used for the diagnosis of migraine. The association between serum magnesium level and migraine headache was analyzed.
A total of 35 children with migraine were enrolled with 35 control subjects. The median (IQR) serum magnesium levels were comparable among children with migraine and controls [2.0 (2.0,2.1) vs 2.2 (1.9, 2.2) mg/dL; P=0.23], respectively. In adolescent sub-group, median (IQR) serum magnesium levels were significantly low among the children with migraine as compared to those without migraine [2.0 (1.9, 2.1) vs 2.2 (2.0, 2.2 mg/dL); P<0.045].
We found a statistically significant association between low serum magnesium levels and the occurrence of migraine in adolescents, which may have treatment implications.
研究血清镁水平与儿童偏头痛之间的关系。
本横断面研究纳入了年龄在 5-18 岁、被诊断为偏头痛的儿童，以及年龄和性别相匹配、无头痛疾病的对照组。采用国际头痛疾病分类第 3 版（ICHD-3）对偏头痛进行诊断。分析血清镁水平与偏头痛头痛之间的关联。
共纳入 35 例偏头痛患儿和 35 例对照患儿。偏头痛患儿和对照组的血清镁中位数（IQR）水平相当[2.0（2.0，2.1）vs 2.2（1.9，2.2）mg/dL；P=0.23]。在青少年亚组中，与无偏头痛的患儿相比，偏头痛患儿的血清镁中位数（IQR）水平显著降低[2.0（1.9，2.1）vs 2.2（2.0，2.2）mg/dL；P<0.045]。
我们发现血清镁水平较低与青少年偏头痛的发生之间存在统计学显著关联，这可能具有治疗意义。
