Department of Nursing, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Department of Emergency Medicine, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.
Int J Lab Hematol. 2022 Oct;44(5):861-867. doi: 10.1111/ijlh.13925. Epub 2022 Jun 24.
This study aimed to explore the relationship between red cell distribution width (RDW) and in-hospital mortality in septic shock based on a large-scale public database.
All patients with septic shock in MIMIC-IV were enrolled. Based on RDW values, the general characteristics of different groups were compared. Different models were constructed for exploring the association of RDW and in-hospital mortality. To assess the predictive value of RDW, receiver operator characteristic (ROC) curve analysis was applied.
A total of 3006 patients with septic shock were included and in-hospital mortality was 32.27% (n = 970). The results of the fully adjusted model demonstrated that RDW was positively associated with in-hospital mortality in septic shock patients after adjusting all confounders (OR = 1.12, 95% CI:1.08-1.17, p < .001). A linear relationship between RDW and in-hospital mortality was found. For predicting in-hospital mortality, the area under the ROC curve (AUC) of RDW was .602 and the best threshold of RDW was 17.25%.
RDW was associated with in-hospital mortality in septic shock. It could be a useful marker for predicting clinical outcomes in septic shock.
本研究旨在基于大型公共数据库探讨红细胞分布宽度（RDW）与脓毒性休克患者院内死亡率之间的关系。
纳入 MIMIC-IV 数据库中所有脓毒性休克患者。根据 RDW 值比较不同组的一般特征。构建不同模型以探讨 RDW 与院内死亡率的相关性。应用受试者工作特征（ROC）曲线分析评估 RDW 的预测价值。
共纳入 3006 例脓毒性休克患者，院内死亡率为 32.27%（n=970）。经所有混杂因素校正的全调整模型结果表明，RDW 与脓毒性休克患者的院内死亡率呈正相关（OR=1.12，95%CI：1.08-1.17，p<0.001）。RDW 与院内死亡率之间存在线性关系。预测院内死亡率时，RDW 的 ROC 曲线下面积（AUC）为 0.602，RDW 的最佳截断值为 17.25%。
RDW 与脓毒性休克患者的院内死亡率相关，可作为预测脓毒性休克患者临床结局的有用标志物。
