Koriem Khaled Mohamed Mohamed, El-Attar Marwa A
Department of Medical Physiology, Medical Research and Clinical Studies Institute, National Research Centre, Dokki, Cairo, Egypt.
Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.
J Complement Integr Med. 2022 Jun 27;19(3):599-606. doi: 10.1515/jcim-2022-0086. eCollection 2022 Sep 1.
Favism is a metabolic disease and this study aimed to compare between olive oil and almond oil to ameliorate blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology in favism rats.
Animals were 36 male albino rats. They classified to 2 equal (normal and favism) groups. Normal group classified to 3 equal subgroups; Control, Olive oil, and Almond oil subgroups: normal rats orally administrated with 1 mL/100 g of saline, olive oil, and almond oil, respectively. Favism group was subdivided into 3 equal subgroup; favism, favism + olive oil, and favism + almond oil subgroups: favism rats orally administrated with no treatment, 1 mL/100 g olive oil, and 1 mL/100 g almond oil, respectively. All treatments were administrated orally by oral gavage once a day for 1 month.
The hemoglobin, hematocrite, the blood cells, glucose and glucose-6-phosphate dehydrogenase, aspartate and alanine aminotransferase, total proteins, albumin, and globulin in serum were decreased in favism. The glutathione, superoxide dismutase, and glutathione peroxidase in blood and liver were decreased in favism while alkaline phosphatase and total bilirubin in serum were increased in favism. The blood and liver malondialdehyde was increased in favism. Furthermore, oral administration with both oils in favism rats restored all these parameters to be approached the control levels. Also, both oils preserved blood and liver DNA and liver histology.
Almond oil restored blood parameters, liver function, blood and liver antioxidants and DNA, and liver histology more efficiently than olive oil in favism.
蚕豆病是一种代谢性疾病，本研究旨在比较橄榄油和杏仁油对改善蚕豆病大鼠血液参数、肝功能、血液和肝脏抗氧化剂及DNA以及肝脏组织学的作用。
实验动物为36只雄性白化大鼠。它们被分为2个相等的组（正常组和蚕豆病组）。正常组又分为3个相等的亚组：对照组、橄榄油亚组和杏仁油亚组，正常大鼠分别口服给予1 mL/100 g生理盐水、橄榄油和杏仁油。蚕豆病组再细分为3个相等的亚组：蚕豆病组、蚕豆病+橄榄油组和蚕豆病+杏仁油组，蚕豆病大鼠分别不进行处理、口服给予1 mL/100 g橄榄油和1 mL/100 g杏仁油。所有处理均通过灌胃每天口服给药1次，持续1个月。
蚕豆病组血清中的血红蛋白、血细胞比容、血细胞、葡萄糖和葡萄糖-6-磷酸脱氢酶、天冬氨酸和丙氨酸转氨酶、总蛋白、白蛋白和球蛋白均降低。蚕豆病组血液和肝脏中的谷胱甘肽、超氧化物歧化酶和谷胱甘肽过氧化物酶降低，而血清中的碱性磷酸酶和总胆红素升高。蚕豆病组血液和肝脏中的丙二醛增加。此外，给蚕豆病大鼠口服这两种油均可使所有这些参数恢复至接近对照水平。而且，这两种油均能保护血液和肝脏DNA以及肝脏组织学。
在蚕豆病大鼠中，杏仁油比橄榄油更有效地恢复血液参数、肝功能、血液和肝脏抗氧化剂及DNA以及肝脏组织学。
