Amamou Fouzia, Nemmiche Saïd, Meziane Radjaa Kaouthar, Didi Amal, Yazit Sidi Mohamed, Chabane-Sari Daoudi
Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria.
Laboratory of natural products, LAPRONA, Faculty of SNV-STU, University of Tlemcen, BP 119 Imama, Tlemcen 13000, Algeria; Department of biology, Faculty of SNV, University of Mostaganem, Mostaganem 27000, Algeria.
Food Chem Toxicol. 2015 Apr;78:177-84. doi: 10.1016/j.fct.2015.01.001. Epub 2015 Jan 21.
Cadmium (Cd) is one of the most common heavy metal pollutants. It is accumulated particularly in liver and kidney. The present study examined the possible protective effect of olive oil and colocynth oil consumption against Cd-induced damage on plasma lipids and stress biochemical parameters of rats. Male albino Wistar rats were randomly divided into 6 groups of 5 animals each and treated orally with Cd (50 mg/l), olive oil and colocynth oil (4%) alone or in combination with cadmium for 8 weeks. It was shown that Cd exposure induced significant increases in the activities of serum alanine aminotransferase, aspartate aminotransferase, lipid peroxidation levels (MDA) and protein carbonyl contents in exposed groups of rats compared to control group while the antioxidant enzymes, reduced glutathione and vitamins (C, A and E) were significantly decreased. Co-treatment with olive oil or colocynth oil significantly improved the oxidative damage induced by Cd. The antioxidant potential in plasma and liver were markedly restored with a significant decline in MDA levels and activity of transaminases. In conclusion, these results suggest that olive oil or colocynth oil consumption could protect the rat liver against Cd-induced injury by increasing the activities of antioxidant enzymes and reducing oxidative stress.
镉（Cd）是最常见的重金属污染物之一。它尤其会在肝脏和肾脏中蓄积。本研究考察了食用橄榄油和苦西瓜油对镉诱导的大鼠血浆脂质损伤及应激生化参数的可能保护作用。将雄性白化Wistar大鼠随机分为6组，每组5只，分别口服镉（50毫克/升）、橄榄油和苦西瓜油（4%），单独或与镉联合使用，持续8周。结果显示，与对照组相比，暴露于镉的大鼠组血清丙氨酸转氨酶、天冬氨酸转氨酶活性、脂质过氧化水平（丙二醛）和蛋白质羰基含量显著增加，而抗氧化酶、还原型谷胱甘肽和维生素（C、A和E）则显著降低。与橄榄油或苦西瓜油共同处理可显著改善镉诱导的氧化损伤。血浆和肝脏中的抗氧化潜能明显恢复，丙二醛水平和转氨酶活性显著下降。总之，这些结果表明，食用橄榄油或苦西瓜油可通过增加抗氧化酶活性和减轻氧化应激来保护大鼠肝脏免受镉诱导的损伤。
