School of Biomedical Engineering, State Key Laboratory of Oncology in South China, Sun Yat-sen University, Shenzhen, 518107, China.
Department of Haematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, 518107, China.
Adv Healthc Mater. 2022 Aug;11(16):e2200494. doi: 10.1002/adhm.202200494. Epub 2022 Jul 6.
Wound healing is a complex biological process that involves tissue regeneration. Traditional wound dressings are dry, cannot provide a moist environment for wound healing, and do not have high antibacterial properties. Hydrogels, which are capable of retaining large amounts of water, can create a moist healing environment. Currently, phototherapies have exhibited a high potential for the treatment of bacterial infections. Therefore, combining hydrogels with phototherapy can adequately overcome the shortcomings of traditional wound treatment methods and show great potential for wound healing owing to their high efficiency, low irritation, and good antibacterial performance. In this review, the application of hydrogels combined with phototherapy in wound healing is summarized. First, the basic principles of photodynamic therapy and photothermal therapy are briefly introduced. In addition, the progress of the application of hydrogel combined with phototherapy in wound healing is systematically investigated. Finally, the challenges and prospects of combining hydrogel with phototherapy in wound healing are discussed.
创伤愈合是一个复杂的生物学过程,涉及组织再生。传统的创伤敷料是干燥的,不能为创伤愈合提供湿润的环境,也没有高的抗菌性能。水凝胶能够保留大量的水分,可以创造一个湿润的愈合环境。目前,光疗在治疗细菌感染方面表现出了很高的潜力。因此,将水凝胶与光疗相结合可以充分克服传统创伤治疗方法的缺点,由于其高效、低刺激和良好的抗菌性能,在创伤愈合方面显示出巨大的潜力。本文总结了水凝胶结合光疗在创伤愈合中的应用。首先,简要介绍了光动力疗法和光热疗法的基本原理。此外,系统地研究了水凝胶结合光疗在创伤愈合中的应用进展。最后,讨论了水凝胶与光疗相结合在创伤愈合中的挑战和前景。