Department of Internal Medicine, University of Tsukuba Hospital, Tsukuba, Ibaraki, Japan.
Department of Emergency and Critical Care Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan.
BMC Res Notes. 2022 Jun 25;15(1):221. doi: 10.1186/s13104-022-06121-0.
Sepsis is a lethal condition characterized by systemic inflammation and multiple organ failure; this condition was initially defined as systemic inflammatory response syndrome (SIRS) due to infection. We previously reported that the hypothalamic neuropeptide orexin improved survival in a murine model of sepsis by mainly acting in the medullary raphe nucleus through orexin type-2 receptors. We hypothesized that orexin treatment enhances recovery from sepsis by reversing the reduction in orexin levels in the cerebrospinal fluid (CSF). We recently reported a case in which CSF orexin levels were reduced in a patient with sepsis. Herein, we attempted to further investigate CSF orexin levels in rats and patients with systemic inflammation. This patient study was a single-center, retrospective observational study.
CSF orexin levels were low in rats with lipopolysaccharide-induced systemic inflammation. We enrolled 14 patients with meningitis/encephalitis. Six patients were diagnosed with SIRS, of whom 5 patients had infections ("sepsis" by the previous definition). CSF orexin levels were low in SIRS patients. The results support the hypothesis that orexin treatment enhances recovery from sepsis by reversing the reduction in CSF orexin levels.
败血症是一种以全身炎症和多器官衰竭为特征的致命病症；这种病症最初因感染被定义为全身炎症反应综合征（SIRS）。我们之前报道过，下丘脑神经肽食欲素通过食欲素 2 型受体主要在延髓中缝核发挥作用，可改善败血症的小鼠模型的存活率。我们假设食欲素治疗通过逆转脑脊液（CSF）中食欲素水平的降低来增强败血症的恢复。我们最近报道了一例败血症患者 CSF 食欲素水平降低的病例。在此，我们试图进一步研究全身炎症大鼠和患者的 CSF 食欲素水平。这项患者研究是一项单中心、回顾性观察性研究。
脂多糖诱导的全身炎症大鼠的 CSF 食欲素水平较低。我们共纳入了 14 名患有脑膜炎/脑炎的患者。6 名患者被诊断为 SIRS，其中 5 名患者有感染（按之前的定义为“败血症”）。SIRS 患者的 CSF 食欲素水平较低。结果支持了这样一种假设，即食欲素治疗通过逆转 CSF 食欲素水平的降低来增强败血症的恢复。
