Blass E, Fitzgerald E, Kehoe P
Pharmacol Biochem Behav. 1987 Mar;26(3):483-9. doi: 10.1016/0091-3057(87)90153-5.
Two experiments were conducted that establish an opioid-based, functional-relationship between the taste of sucrose, pain threshold and distress vocalization in isolated 10-day-old albino rats. In the first experiment intraoral infusion of sucrose virtually doubled heat-withdrawal latencies. This elevation was naltrexone (0.5 mg/kg b.wt.) reversible. In the second experiment sucrose infusions caused a rapid and sustained diminution of distress vocalizations in rats totally isolated from dam and siblings. These are the first demonstrations of a causal relationship between a positive affective system and ones mediating pain and stress.
进行了两项实验，确立了10日龄隔离饲养的白化大鼠中蔗糖味道、痛阈和痛苦发声之间基于阿片类物质的功能关系。在第一个实验中，口腔内输注蔗糖实际上使热退缩潜伏期增加了近一倍。这种升高可被纳曲酮（0.5毫克/千克体重）逆转。在第二个实验中，蔗糖输注使与母鼠和同胞完全隔离的大鼠的痛苦发声迅速且持续减少。这些首次证明了积极情感系统与介导疼痛和应激的系统之间的因果关系。
