Iseki Mari, Nakayama Hiroki, Watanabe Mutsufusa, Uchibori Ayumi, Chiba Atsuro, Mizutani Saneyuki
Department of Neurology, Tokyo Metropolitan Bokutoh Hospital.
Department of Neurology, Kyorin University Hospital.
Rinsho Shinkeigaku. 2022 Jul 29;62(7):558-562. doi: 10.5692/clinicalneurol.cn-001750. Epub 2022 Jun 24.
A 43-year-old-woman developed paresthesia, weakness of limbs, dysphagia and deep sensory impairment 12 days after vaccination of Pfizer COVID-19 vaccine. Her deep tendon reflexes were absent and cerebrospinal fluid showed normal cell counts and protein level. Anti-ganglioside antibodies were negative, and F wave frequency was decreased in nerve conduction studies. We diagnosed her as immune mediated polyneuropathy caused by COVID-19 vaccine, and plasma exchange improved her symptoms. Compared with Guillain-Barré syndrome and polyneuropathy following COVID-19 infection and COVID-19 vaccination, deep sensory impairment was the most characteristic of this case. We supposed that non-antigen specific mechanism played an important role in the pathogenesis of this case.
