Clinical Immunology Allergy and AIDS Center, Kaplan Medical Center, Rehovot, Israel.
Clalit Health Services, Rishon LeZion, Israel.
Pediatr Allergy Immunol. 2022 Jun;33(6). doi: 10.1111/pai.13819.
Previous studies reported controversial results regarding the association between allergic disorders and attention deficit hyperactivity disorder (ADHD)/autism spectrum disorder (ASD). The aim of this article was to investigate whether allergic disorders are associated with ADHD/ASD in a large cohort of pediatric patients.
A retrospective study using the pediatric (0-18 year) database (ICD-9-CM codes) of Clalit Health Services during the years (2000-2018). Diagnosis of all disorders was made by specialist physicians.
A total of 117 022 consecutive non-selective allergic children diagnosed with one or more allergic disorder (asthma, rhinitis, conjunctivitis, skin, food, or drug allergy) and 116 968 non-allergic children were enrolled to our study. The mean follow-up period was 11 ± 6 years. The presence of allergic disorders in early childhood (mean age of allergic diagnosis 4.5 ± 4.3 years) in boys as well as in girls significantly increased the risk to develop ADHD (O.R 2.45, CI 2.39-2.51; p < .0001), ASD (O.R 1.17, CI 1.08-1.27; p < .0001), or both ADHD + ASD (O.R 1.5, CI 1.35-1.79; p < .0001). Children with more than one allergic comorbidity revealed a much higher risk. In a multivariable analysis (adjusted for age at study entry, number of yearly visits, and gender), the risk of allergic children to develop ADHD and ADHD + ASD, but not ASD alone, remained significantly higher.
Allergic disorder in early childhood significantly increased the risk to develop ADHD, and to a less extend ASD, in later life.
先前的研究报告称，过敏症与注意力缺陷多动障碍（ADHD）/自闭症谱系障碍（ASD）之间的关联存在争议。本文旨在调查在大型儿科患者队列中，过敏症是否与 ADHD/ASD 相关。
这是一项使用 Clalit 健康服务的儿科（0-18 岁）数据库（ICD-9-CM 代码）进行的回顾性研究，研究时间为 2000 年至 2018 年。所有疾病的诊断均由专科医生做出。
共纳入 117022 例连续的非选择性过敏儿童，这些儿童被诊断为一种或多种过敏疾病（哮喘、鼻炎、结膜炎、皮肤、食物或药物过敏），以及 116968 例非过敏儿童。平均随访时间为 11±6 年。男孩和女孩在幼儿期（过敏诊断的平均年龄为 4.5±4.3 岁）存在过敏疾病显著增加了患 ADHD（O.R 2.45，CI 2.39-2.51；p<0.0001）、ASD（O.R 1.17，CI 1.08-1.27；p<0.0001）或两者同时存在（ADHD+ASD；O.R 1.5，CI 1.35-1.79；p<0.0001）的风险。有多种过敏合并症的儿童风险更高。在多变量分析（调整研究时的年龄、每年就诊次数和性别）中，过敏儿童患 ADHD 和 ADHD+ASD 的风险显著更高，但患 ASD 的风险则不然。
幼儿期的过敏症显著增加了儿童日后患 ADHD 的风险，并且在较小程度上增加了患 ASD 的风险。
