Al-Fakhry Hakam H, Al-Sayagh Nada M
Department of Orthodontics, Collage of Dentistry, University of Mosul, Iraq.
J Orthod Sci. 2022 May 4;11:10. doi: 10.4103/jos.jos_165_21. eCollection 2022.
The objective of this study is to determine whether submucosal local injection of i-PRF may affect orthodontic relapse by increasing bone density, which further leads to reducing orthodontic relapse.
Forty-five adult male albino rabbits were randomly divided into three groups: group I (control) with 15 rabbits injected with 200 μl of phosphate-buffered saline (PBS), group II with 15 rabbits injected with 200 μl of i-PRF, and group III of 15 rabbits inject with 400 μl of i-PRF. The lower incisors of rabbits moved distally by a modified orthodontic appliance for 2 weeks; then, the appliance was maintained in position to retain the gaining space for 2 weeks. During the retention period, each group was injected with the specific drug every 7 days. After the retention period, teeth were allowed to relapse by removal of the orthodontic appliance. The results were evaluated by measuring the amount of orthodontic relapse and bone density. The statistical analysis performed by ANOVA and Duncan ( < 0.05 was considered significant).
I-PRF groups showed a significant reduction in the amount of relapse at 10, 13, 17, and 20 days compared to the control group, indicated by the highest percentage of relapse for the control group at the end of the study (20 days); it was (90.4%) in compared to lowest percentage of relapse for i-PRF groups-they were 61.2% and 59.9%, respectively.
Results indicated that i-PRF has the potential to enhance the stability of teeth after orthodontic tooth movement and could have the ability to reduce relapse, probably by increasing the alveolar bone density.
本研究的目的是确定黏膜下局部注射富血小板纤维蛋白（i-PRF）是否可通过增加骨密度来影响正畸复发，进而减少正畸复发。
45只成年雄性白化兔随机分为三组：第一组（对照组）15只，注射200μl磷酸盐缓冲盐水（PBS）；第二组15只，注射200μl i-PRF；第三组15只，注射400μl i-PRF。用改良的正畸矫治器使兔的下切牙向远中移动2周；然后，保持矫治器在位以维持获得的间隙2周。在保持期内，每组每7天注射特定药物。保持期结束后，去除正畸矫治器使牙齿复发。通过测量正畸复发量和骨密度来评估结果。采用方差分析和邓肯检验进行统计分析（P<0.05认为有统计学意义）。
与对照组相比，i-PRF组在第10、13、17和20天时复发量显著降低，研究结束时（20天）对照组的复发率最高（90.4%），而i-PRF组的复发率最低，分别为61.2%和59.9%。
结果表明，i-PRF有可能增强正畸牙齿移动后牙齿的稳定性，并可能有减少复发的能力，可能是通过增加牙槽骨密度实现的。
