Proença Ana Carolina, Luís Ângelo, Duarte Ana Paula
Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Avenida Infante D. Henrique, Covilhã 6200-506, Portugal.
Pharmaco-Toxicology Laboratory, UBIMedical, University of Beira Interior, Estrada Municipal 506, Covilhã 6200-284, Portugal.
Evid Based Complement Alternat Med. 2022 Jun 15;2022:2011945. doi: 10.1155/2022/2011945. eCollection 2022.
Over the past few decades, interest in medicinal plants and phytochemicals for the treatment of skin disorders, including acne vulgaris, has progressively increased. Acne vulgaris is a chronic inflammatory disease of the pilosebaceous unit, which mainly occurs in adolescents and young adults. The treatment focuses on the four main factors involved in its pathogenesis: increased sebum production, hyperkeratinization, overgrowth of , and inflammation. The treatment includes topical retinoids, benzoyl peroxide, antibiotics, and oral isotretinoin. In this regard, the use of herbal medicine as a complementary and alternative medicine is a promising strategy. The main objective of this study was to systematically evaluate the efficacy and safety of medicinal plants and phytochemicals in the treatment of acne vulgaris. Three scientific databases (PubMed, Web of Science, and Scopus) were searched from inception to January 2021. Clinical trials comparing herbal therapies with placebo or other medicines for the treatment of acne vulgaris were included and analyzed. Outcome measures of interest comprised acne lesions (inflammatory and noninflammatory), sebum production, acne severity, and quality of life. The risk of bias in the included randomized controlled trials (RCTs) was assessed using the Cochrane risk-of-bias tool. A total of 34 clinical trials involving 1753 participants met the inclusion criteria for this systematic review. Most trials showed that herbal medicine significantly reduces inflammatory and noninflammatory acne lesions and has a relevant effect on acne severity. Some medicinal plants revealed equal or higher efficacy to standard treatments. No significant difference between groups in sebum production and quality of life was observed and no severe adverse events were reported. This systematic review provides evidence that medicinal plants and phytochemicals are promising treatments for mild to moderate acne vulgaris. However, more quality of evidence and standardized methodologies are needed to support their effectiveness and safety claims.
在过去几十年中，人们对用于治疗包括寻常痤疮在内的皮肤疾病的药用植物和植物化学物质的兴趣日益增加。寻常痤疮是一种毛囊皮脂腺单位的慢性炎症性疾病，主要发生在青少年和青年成年人中。治疗重点在于其发病机制中涉及的四个主要因素：皮脂分泌增加、过度角化、痤疮丙酸杆菌过度生长以及炎症。治疗方法包括外用维甲酸、过氧化苯甲酰、抗生素和口服异维甲酸。在这方面，使用草药作为补充和替代医学是一种有前景的策略。本研究的主要目的是系统评价药用植物和植物化学物质治疗寻常痤疮的疗效和安全性。检索了三个科学数据库（PubMed、科学网和Scopus），检索时间从建库至2021年1月。纳入并分析了比较草药疗法与安慰剂或其他药物治疗寻常痤疮的临床试验。感兴趣的结局指标包括痤疮皮损（炎性和非炎性）、皮脂分泌、痤疮严重程度和生活质量。使用Cochrane偏倚风险工具评估纳入的随机对照试验（RCT）中的偏倚风险。共有34项涉及1753名参与者的临床试验符合本系统评价的纳入标准。大多数试验表明草药能显著减少炎性和非炎性痤疮皮损，并对痤疮严重程度有相关影响。一些药用植物显示出与标准治疗相当或更高的疗效。未观察到两组在皮脂分泌和生活质量方面有显著差异，也未报告严重不良事件。本系统评价提供了证据表明药用植物和植物化学物质是治疗轻度至中度寻常痤疮的有前景的疗法。然而，需要更多高质量的证据和标准化方法来支持它们的有效性和安全性声明。
