• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

超临界流体萃取法对Endl.四部提取物的成分分析及其对RAW 264.7细胞的抗炎作用

Component analysis of four-part extracts from Endl. by supercritical fluid extraction and anti-inflammatory effect on RAW 264.7cells.

作者信息

Kwak Byeong Mun, Kim Ee-Hwa, Kim Yong-Min, Kim Hee-Tack

机构信息

Department of Meridian & Acupoint, College of Korean Medicine, Semyung University, Jecheon, Korea.

Department of Oriental Medical and Herbal Cosmetic Sciences, Semyung University, Jecheon, Korea.

出版信息

J Exerc Rehabil. 2019 Oct 28;15(5):723-730. doi: 10.12965/jer.1938442.221. eCollection 2019 Oct.

DOI:10.12965/jer.1938442.221
PMID:31723563
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6834702/
Abstract

The main purpose of this study was to suggest a solution for inflammation caused by urban daily life based on supercritical extraction of Endl. (). The leaves, cone, wood, and bark of were separately extracted with supercritical extraction. Alpha-pinene, anti-inflammatory active compound of , was analyzed by electrospray ionization-mass spectrometry, gas chromatography, and gas chromatography mass spectrometry from each part of extracts. As a result of the reduction rate of nitric oxide in RAW 264.7 cells, the wood extract exhibited the highest reduction rate was about 45% among extracts from four part of . The wood extract from can be developed as a good anti-inflammatory natural raw material for natural product industry.

摘要

本研究的主要目的是基于对[植物名称未完整给出]的超临界萃取，为城市日常生活引起的炎症提出一种解决方案。分别用超临界萃取法对[植物名称未完整给出]的叶子、球果、木材和树皮进行萃取。通过电喷雾电离质谱、气相色谱和气相色谱质谱联用，对各萃取部位的α-蒎烯（[植物名称未完整给出]的抗炎活性化合物）进行分析。以RAW 264.7细胞中一氧化氮的减少率为结果，木材提取物在[植物名称未完整给出]四个部位的提取物中表现出最高的减少率，约为45%。[植物名称未完整给出]的木材提取物可开发成为天然产品行业中一种优良的抗炎天然原料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/d5364038b761/jer-15-5-723f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/49e43469f1c5/jer-15-5-723f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/6860bdeb80d5/jer-15-5-723f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/c59c91ea71fe/jer-15-5-723f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/f6c99d2ec799/jer-15-5-723f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/a6d58c09bb0d/jer-15-5-723f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/d5364038b761/jer-15-5-723f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/49e43469f1c5/jer-15-5-723f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/6860bdeb80d5/jer-15-5-723f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/c59c91ea71fe/jer-15-5-723f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/f6c99d2ec799/jer-15-5-723f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/a6d58c09bb0d/jer-15-5-723f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5cb1/6834702/d5364038b761/jer-15-5-723f6.jpg

相似文献

1
Component analysis of four-part extracts from Endl. by supercritical fluid extraction and anti-inflammatory effect on RAW 264.7cells.超临界流体萃取法对Endl.四部提取物的成分分析及其对RAW 264.7细胞的抗炎作用
J Exerc Rehabil. 2019 Oct 28;15(5):723-730. doi: 10.12965/jer.1938442.221. eCollection 2019 Oct.
2
Chamaecyparis obtusa (Siebold & Zucc.) Endl. leaf extracts prevent inflammatory responses via inhibition of the JAK/STAT axis in RAW264.7 cells.圆柏（Siebold & Zucc.）Endl. 叶提取物通过抑制 RAW264.7 细胞中的 JAK/STAT 轴来预防炎症反应。
J Ethnopharmacol. 2022 Jan 10;282:114493. doi: 10.1016/j.jep.2021.114493. Epub 2021 Aug 5.
3
Anti-Inflammatory Effect of (Siebold & Zucc.) Endl. Leaf Essential Oil.（Siebold & Zucc.）Endl.叶精油的抗炎作用。
Molecules. 2024 Mar 1;29(5):1117. doi: 10.3390/molecules29051117.
4
Pharmacological anti-tumor effects of natural Chamaecyparis obtusa (siebold & zucc.) endl. Leaf extracts on breast cancer.天然扁柏（Siebold & Zucc.）叶提取物对乳腺癌的药理抗肿瘤作用。
J Ethnopharmacol. 2023 Sep 15;313:116598. doi: 10.1016/j.jep.2023.116598. Epub 2023 May 3.
5
Supercritical CO2 extraction of essential oils from Chamaecyparis obtusa.超临界二氧化碳萃取钝叶扁柏精油
Nat Prod Commun. 2010 Mar;5(3):461-4.
6
The Precious Potential of the Sacred Tree (Siebold & Zucc.) Endl. as a Source of Secondary Metabolites with Broad Biological Applications.神圣树（Siebold & Zucc.）Endl. 作为具有广泛生物学应用的次生代谢产物来源的宝贵潜力。
Int J Mol Sci. 2024 Feb 27;25(5):2723. doi: 10.3390/ijms25052723.
7
Antiproliferative and Apoptotic Activity of Chamaecyparis obtusa Leaf Extract against the HCT116 Human Colorectal Cancer Cell Line and Investigation of the Bioactive Compound by Gas Chromatography-Mass Spectrometry-Based Metabolomics.钝叶扁柏叶提取物对HCT116人结肠癌细胞系的抗增殖和凋亡活性及基于气相色谱-质谱联用代谢组学的生物活性化合物研究
Molecules. 2015 Oct 2;20(10):18066-82. doi: 10.3390/molecules201018066.
8
Chamaecyparis obtusa Essential Oil Inhibits Methicillin-Resistant Staphylococcus aureus Biofilm Formation and Expression of Virulence Factors.钝叶扁柏精油抑制耐甲氧西林金黄色葡萄球菌生物膜形成及毒力因子表达。
J Med Food. 2015 Jul;18(7):810-7. doi: 10.1089/jmf.2014.3309. Epub 2015 Apr 29.
9
Biological Activity and Component Analyses of Leaf Extract: Evaluation of Antiwrinkle and Cell Protection Effects in UVA-Irradiated Cells.叶提取物的生物活性和成分分析：评价其对 UVA 照射细胞的抗皱和细胞保护作用。
Medicina (Kaunas). 2023 Apr 13;59(4):755. doi: 10.3390/medicina59040755.
10
Chemical composition and anti-inflammatory activity of Chamaecyparis obtusa f.formosana wood essential oil from Taiwan.台湾台湾扁柏木材精油的化学成分及抗炎活性
Nat Prod Commun. 2014 May;9(5):723-6.

引用本文的文献

1
Protective effects of α-Pinene against carbon tetrachloride-induced cardiac injury in Wistar rats: modulation of antioxidant and inflammatory responses.α-蒎烯对四氯化碳诱导的Wistar大鼠心脏损伤的保护作用：对抗氧化和炎症反应的调节
Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar;398(3):2845-2854. doi: 10.1007/s00210-024-03434-8. Epub 2024 Sep 19.
2
The Precious Potential of the Sacred Tree (Siebold & Zucc.) Endl. as a Source of Secondary Metabolites with Broad Biological Applications.神圣树（Siebold & Zucc.）Endl. 作为具有广泛生物学应用的次生代谢产物来源的宝贵潜力。
Int J Mol Sci. 2024 Feb 27;25(5):2723. doi: 10.3390/ijms25052723.
3

本文引用的文献

1
Neurologic Mechanisms Underlying Voiding Dysfunction due to Prostatitis in a Rat Model of Nonbacterial Prostatic Inflammation.非细菌性前列腺炎大鼠模型中前列腺炎所致排尿功能障碍的神经机制
Int Neurourol J. 2018 Jun;22(2):90-98. doi: 10.5213/inj.1836124.062. Epub 2018 Jun 30.
2
Near-Normalized Gene Expression Profiles in Bladder With Detrusor Overactivity in Rats With Bladder Outlet Obstruction After Deobstruction.解除梗阻后膀胱出口梗阻大鼠逼尿肌过度活动膀胱中的近正常基因表达谱
Int Neurourol J. 2017 Dec;21(4):247-258. doi: 10.5213/inj.1732774.387. Epub 2017 Dec 31.
3
Comparison of 5 Different Rat Models to Establish a Standard Animal Model for Research Into Interstitial Cystitis.
The Role of Herbal Medicine in the Treatment of Acne Vulgaris: A Systematic Review of Clinical Trials.
草药医学在寻常痤疮治疗中的作用：临床试验的系统评价
Evid Based Complement Alternat Med. 2022 Jun 15;2022:2011945. doi: 10.1155/2022/2011945. eCollection 2022.
4
A Review of the Potential Use of Pinene and Linalool as Terpene-Based Medicines for Brain Health: Discovering Novel Therapeutics in the Flavours and Fragrances of Cannabis.松油烯和芳樟醇作为基于萜烯的脑健康药物的潜在用途综述：在大麻的风味和香气中发现新型疗法
Front Psychiatry. 2021 Aug 26;12:583211. doi: 10.3389/fpsyt.2021.583211. eCollection 2021.
5
Immunomodulative Effects of Essential Oil in Mouse Model of Allergic Rhinitis.精油对变应性鼻炎小鼠模型的免疫调节作用。
Molecules. 2020 Oct 2;25(19):4517. doi: 10.3390/molecules25194517.
五种不同大鼠模型用于建立间质性膀胱炎研究标准动物模型的比较
Int Neurourol J. 2017 Sep;21(3):163-170. doi: 10.5213/inj.1734898.449. Epub 2017 Sep 12.
4
Alpha-Pinene Exhibits Anti-Inflammatory Activity Through the Suppression of MAPKs and the NF-κB Pathway in Mouse Peritoneal Macrophages.α-蒎烯通过抑制小鼠腹腔巨噬细胞中 MAPKs 和 NF-κB 通路发挥抗炎活性。
Am J Chin Med. 2015;43(4):731-42. doi: 10.1142/S0192415X15500457. Epub 2015 Jun 28.
5
Anti-inflammatory and chondroprotective activity of (+)-α-pinene: structural and enantiomeric selectivity.(+)-α-蒎烯的抗炎和软骨保护活性：结构和对映体选择性。
J Nat Prod. 2014 Feb 28;77(2):264-9. doi: 10.1021/np400828x. Epub 2014 Jan 23.
6
Essential oils from Distichoselinum tenuifolium: chemical composition, cytotoxicity, antifungal and anti-inflammatory properties.二色千里光中的精油：化学成分、细胞毒性、抗真菌和抗炎特性。
J Ethnopharmacol. 2010 Aug 9;130(3):593-8. doi: 10.1016/j.jep.2010.05.054. Epub 2010 Jun 9.
7
Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation.慢性炎症：NOD2和NALP3在白细胞介素-1β生成中的重要性
Clin Exp Immunol. 2007 Feb;147(2):227-35. doi: 10.1111/j.1365-2249.2006.03261.x.
8
Anti-TNF-alpha therapies: the next generation.抗肿瘤坏死因子-α疗法：下一代疗法
Nat Rev Drug Discov. 2003 Sep;2(9):736-46. doi: 10.1038/nrd1175.
9
Effect of long-term use of moisturizer on skin hydration, barrier function and susceptibility to irritants.长期使用保湿剂对皮肤水合作用、屏障功能及刺激物易感性的影响。
Acta Derm Venereol. 1999 Jan;79(1):49-51. doi: 10.1080/000155599750011705.
10
Proinflammatory and anti-inflammatory cytokines as mediators in the pathogenesis of septic shock.促炎和抗炎细胞因子作为脓毒性休克发病机制中的介质。
Chest. 1997 Dec;112(6 Suppl):321S-329S. doi: 10.1378/chest.112.6_supplement.321s.