Department of Infectious Diseases, Hospital Clinic of Barcelona, Barcelona, Spain.
University of Barcelona, Barcelona, Spain.
Front Cell Infect Microbiol. 2022 Jun 10;12:899257. doi: 10.3389/fcimb.2022.899257. eCollection 2022.
Fecal microbiota transplantation (FMT) is one of the recommended treatments for recurrent infection, but endoscopy and available oral formulations still have several limitations in their preparation, storage, and administration. The need for a viable oral formulation that facilitates the implementation of this highly effective therapy in different settings has led us to test the microcrystalline cellulose particles as an adsorbent of concentrated filtered fresh feces in comparison to lyophilized feces. This free-flowing material can provide protection to bacteria and results in a dried product able to maintain the viability of the microbiota for a long time. Adsorbate formulation showed a stabilizing effect in gut microbiota, maintaining bacteria viability and preserving its diversity, and is a competitive option for lyophilized capsules.
粪便微生物群移植（FMT）是复发性感染的推荐治疗方法之一，但内窥镜检查和现有的口服制剂在制备、储存和给药方面仍存在一些限制。需要一种可行的口服制剂，以方便在不同环境下实施这种高效治疗，这促使我们测试微晶纤维素颗粒作为浓缩过滤新鲜粪便的吸附剂，与冻干粪便进行比较。这种自由流动的材料可以为细菌提供保护，形成一种干燥产品，能够长时间保持微生物群的活力。吸附剂配方对肠道微生物群具有稳定作用，保持细菌活力并保持其多样性，是冻干胶囊的一种有竞争力的选择。
