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聚多巴胺:抗菌潜力的利用——综述

Polydopamine, harness of the antibacterial potentials-A review.

作者信息

He Xiaojun, Obeng Enoch, Sun Xiaoshuai, Kwon Nahyun, Shen Jianliang, Yoon Juyoung

机构信息

School of Ophthalmology & Optometry, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.

Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, 325000, China.

出版信息

Mater Today Bio. 2022 Jun 16;15:100329. doi: 10.1016/j.mtbio.2022.100329. eCollection 2022 Jun.

Abstract

Antibiotic resistance is one of the major causes of morbidity and mortality, triggered by the adhesion of microbes and to some extent the formation of biofilms. This condition has been quite challenging in the health and industrial sector. Conditions and processes required to foil these infectious and resistance are of much concern. The synthesis of PDA material, inspired by the foot protein (MEFP)5 possesses unique characteristics that allow for, adhesion, photothermal therapy, synergistic effects with other materials, biocompatibility process, etc. Therefore, their usage holds great potential for dealing with both the infectious nature and the antibiotic resistance processes. Hence, this review provides an overview of the mechanism involved in accomplishing and eradicating bacteria, the recently harnessed antibacterial effect of the PDA through other properties they possess, a way forward in tapping the benefit embedded in the PDA, and the future perspective.

摘要

抗生素耐药性是发病率和死亡率的主要原因之一,由微生物的粘附以及在一定程度上生物膜的形成引发。这种情况在卫生和工业领域一直颇具挑战性。挫败这些感染和耐药性所需的条件和过程备受关注。受足部蛋白质(MEFP)5启发合成的聚多巴胺(PDA)材料具有独特的特性,可实现粘附、光热疗法、与其他材料的协同效应、生物相容性过程等。因此,它们的使用在应对感染性和抗生素耐药过程方面具有巨大潜力。因此,本综述概述了实现和根除细菌所涉及的机制、PDA最近通过其拥有的其他特性所发挥的抗菌作用、挖掘PDA潜在益处的前进方向以及未来展望。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/02b8/9218838/7a59912e0a94/ga1.jpg

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