Institute of Plant Protection, Henan Key Laboratory of Crop Pest Control, Key Laboratory of Integrated Pest Management on Crops in Southern Region of North China, Henan Academy of Agricultural Sciences, Zhengzhou, China.
College of Plant Protection, Henan Agricultural University, Zhengzhou, China.
Front Immunol. 2022 Jun 9;13:905628. doi: 10.3389/fimmu.2022.905628. eCollection 2022.
Densoviruses (DVs) are single-stranded DNA viruses and exclusively happen in invertebrates. Most of DVs reported in insects are pathogenic to their native hosts, however, no pathogenic effect of them has been examined in vertebrates. Hence, DVs are the potential agents used in pest managements. Aphids are the primary vectors of plant viruses. In this study, we identified a novel DV in Chinese population, provisionally named "Sitobion miscanthi densovirus" (SmDV). Taxonomically, SmDV belongs to genus . In , SmDV is hosted in diverse cells and can be horizontally transmitted wheat feeding. Subject to SmDV, aphids activate their intrinsic antiviral autophagy pathway. Grouped with ascorbate and aldarate metabolism, chlorophyll metabolism, p450 related drug metabolism, and retinoid metabolism, aphids form a complex immune network response to the infection of SmDV. Obviously, it works as elder aphids still alive even they contain the highest examined concentration of SmDV. This study provides a foundation for the identifications of novel DVs, and further improves the understanding of the molecular interactions between insects and DVs.
浓核病毒（DVs）是单链 DNA 病毒，仅存在于无脊椎动物中。已报道的昆虫中的大多数 DVs 对其原生宿主具有致病性，但尚未在脊椎动物中检查到它们的致病作用。因此，DVs 是害虫管理中潜在的作用因子。蚜虫是植物病毒的主要载体。在这项研究中，我们在中国种群中鉴定出一种新型的 DV，暂命名为“荻草谷网蚜浓核病毒”（SmDV）。从分类学上讲，SmDV 属于属 。在中国，SmDV 存在于多种细胞中，并可以通过取食小麦进行水平传播。在 SmDV 的作用下，蚜虫激活其内在的抗病毒自噬途径。与抗坏血酸和醛酸盐代谢、叶绿素代谢、p450 相关药物代谢和视黄醇代谢一起，蚜虫形成一个复杂的免疫网络来应对 SmDV 的感染。显然，即使含有最高检测浓度的 SmDV，老蚜虫仍然存活。这项研究为新型 DVs 的鉴定提供了基础，并进一步提高了对昆虫与 DVs 之间分子相互作用的理解。
