甲基化作为隐匿性宫颈癌和高级宫颈上皮内瘤变的筛查标志物。
Methylated as a triage marker for occult cervical cancer and advanced cervical intraepithelial neoplasia.
机构信息
Gynecology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Pathology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
出版信息
Future Oncol. 2022 Jul;18(23):2583-2592. doi: 10.2217/fon-2021-1625. Epub 2022 Jun 27.
To explore the appropriate triage methods for women infected with high-risk human papillomavirus (hrHPV). A total of 424 out of 872 hrHPV-infected women were divided into cervicitis (n = 123), cervical intraepithelial neoplasia grade 1 (CIN1; n = 89), CIN2 (n = 72), CIN3 (n = 87) and cervical cancer (n = 53) groups. The sensitivity/specificity of , and liquid-based cytology (LBC) for hrHPV-infected women with transformation zone 3 CIN3+ was 83.9/93.1, 77.4/90.6 and 80.6/58.5%, respectively. The / test had a higher specificity than LBC (p < 0.001) and similar sensitivity to that observed for LBC (p > 0.05). / improved the positive predictive value of CIN3+ (64.7/60.0%) in low-grade LBC (negative predictive value: 91.7/88.7%). was superior to and LBC tests in detecting CIN3+ in hrHPV-infected women.
为了探索针对高危型人乳头瘤病毒（hrHPV）感染女性的合适分诊方法。将 872 例 hrHPV 感染女性中的 424 例分为宫颈炎（n=123）、宫颈上皮内瘤变 1 级（CIN1；n=89）、CIN2（n=72）、CIN3（n=87）和宫颈癌（n=53）组。液基细胞学（LBC）、液基细胞学和细胞学（）对于转化区 3 CIN3+的 hrHPV 感染女性的敏感性/特异性分别为 83.9/93.1、77.4/90.6 和 80.6/58.5%。/试验的特异性高于 LBC（p<0.001），与 LBC 的敏感性相似（p>0.05）。/提高了低级别 LBC 中 CIN3+的阳性预测值（64.7/60.0%）（阴性预测值：91.7/88.7%）。/在检测 hrHPV 感染女性的 CIN3+方面优于和 LBC 试验。
Zotero 插件