Jurek Joanna, Owczarek Marcin, Godos Justyna, La Vignera Sandro, Condorelli Rosita A, Marventano Stefano, Tieri Maria, Ghelfi Francesca, Titta Lucilla, Lafranconi Alessandra, Gambera Angelo, Alonzo Elena, Sciacca Salvatore, Buscemi Silvio, Ray Sumantra, Del Rio Daniele, Galvano Fabio, Grosso Giuseppe
APC Microbiome Ireland, University College Cork, Cork, Ireland.
Ulster University, Coleraine, UK.
Int J Food Sci Nutr. 2022 Nov;73(7):851-860. doi: 10.1080/09637486.2022.2090520. Epub 2022 Jun 26.
Fish represents one of the most important dietary sources of omega-3 polyunsaturated fatty acids, which are known to be associated with various health benefits. This study aimed to systematically review existing meta-analyses of observational studies exploring the association between fish intake and various health outcomes. A systematic search of electronic databases was conducted to retrieve a total of 63 studies. Evidence was deemed as possible for the association between higher fish intake and decreased risk of the acute coronary syndrome, liver cancer, and depression, and limited for other outcomes (including age-related macular degeneration, Alzheimer's disease, heart failure, all-cause and coronary heart disease mortality, total and ischaemic stroke) due to heterogeneity between results and potential otherwise inexplicable confounding factors. In conclusion, results from epidemiological studies support the mechanistic effects associated with omega-3 fatty acids from high fish consumption, but evidence needs to be further corroborated with more reliable results.
鱼类是ω-3多不饱和脂肪酸最重要的饮食来源之一，已知这些脂肪酸对健康有诸多益处。本研究旨在系统回顾现有关于观察性研究的荟萃分析，这些研究探讨了鱼类摄入量与各种健康结果之间的关联。我们对电子数据库进行了系统检索，共检索到63项研究。有证据表明，较高的鱼类摄入量与急性冠状动脉综合征、肝癌和抑郁症风险降低之间可能存在关联，而对于其他结果（包括年龄相关性黄斑变性、阿尔茨海默病、心力衰竭、全因死亡率和冠心病死亡率、总中风和缺血性中风），由于结果之间的异质性和其他潜在的无法解释的混杂因素，证据有限。总之，流行病学研究结果支持高鱼类消费中ω-3脂肪酸相关的机制效应，但证据需要更可靠的结果进一步证实。
