Department of Acute Infectious Disease Control and Prevention, Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China.
Department of Infectious Diseases, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Immun Inflamm Dis. 2022 Jul;10(7):e664. doi: 10.1002/iid3.664.
Emerging variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have resulted in new challenges for epidemic prevention and control worldwide. However, little is known about the latent period of coronavirus disease by the SARS-CoV-2 Delta variant of concern (VOC) in the postvaccination era.
The epidemiology and clinical data of cases with confirmed SARS-CoV-2 Delta VOC infection were retrospective collected. Dates of the first positive PCR test were collected to estimate the distribution of latent period.
Of the 40 patients, 16 were male (40%). The median age of patients was 47.5 years. The median latent period of patients was 6.0 days (interquartile range [IQR], 4.0-9.0 days) and the longest latent period was 13.0 days after exposure. The latent periods were longer in male patients compared to female patients (median, 8.5 days vs. 5.0 days, p = .041). The median latent period was comparable among fully vaccinated cases (6.5 days), no vaccinated cases (7.5 days), and partially vaccinated cases (5.5 days).
The median latent period of SARS-CoV-2 Delta VOC infection was 6.0 days. The latent period between vaccinated and non-vaccinated patients was not significantly different. The 14-day quarantine program is sufficient to prevent the transmission of COVID-19 by Delta VOC in the postvaccination era.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的新兴变体导致了全球防疫的新挑战。然而，对于接种疫苗后的 SARS-CoV-2 Delta 变体关注（VOC）引起的新冠疾病的潜伏期知之甚少。
回顾性收集了确诊 SARS-CoV-2 Delta VOC 感染病例的流行病学和临床数据。收集了首次阳性 PCR 检测日期，以估计潜伏期分布。
40 例患者中，男性 16 例（40%）。患者的中位年龄为 47.5 岁。患者的中位潜伏期为 6.0 天（四分位距 [IQR]，4.0-9.0 天），最长潜伏期为暴露后 13.0 天。男性患者的潜伏期长于女性患者（中位数，8.5 天比 5.0 天，p=0.041）。完全接种疫苗的病例（6.5 天）、未接种疫苗的病例（7.5 天）和部分接种疫苗的病例（5.5 天）的中位潜伏期相似。
SARS-CoV-2 Delta VOC 感染的中位潜伏期为 6.0 天。接种疫苗和未接种疫苗患者的潜伏期没有显著差异。在接种疫苗后，14 天的隔离计划足以预防 Delta VOC 引起的 COVID-19 的传播。
