Qi Hai, Liu Bo, Wang Xinquan, Zhang Linqi
Tsinghua-Peking Center for Life Sciences, Beijing, China.
Laboratory of Dynamic Immunobiology, Institute for Immunology, Tsinghua University, Beijing, China.
Nat Immunol. 2022 Jul;23(7):1008-1020. doi: 10.1038/s41590-022-01248-5. Epub 2022 Jun 27.
Two and a half years into the COVID-19 pandemic, we have gained many insights into the human antibody response to the causative SARS-CoV-2 virus. In this Review, we summarize key observations of humoral immune responses in people with COVID-19, discuss key features of infection- and vaccine-induced neutralizing antibodies, and consider vaccine designs for inducing antibodies that are broadly protective against different variants of the SARS-CoV-2 virus.
在新冠疫情爆发两年半之际，我们对人类针对致病的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的抗体反应有了许多深入了解。在本综述中，我们总结了新冠病毒感染者体液免疫反应的关键观察结果，讨论了感染诱导和疫苗诱导的中和抗体的关键特征，并考虑了用于诱导对SARS-CoV-2病毒不同变体具有广泛保护作用的抗体的疫苗设计。
