Twohig Frances M, Baranowski Tonilynn M, Ye Chunyan, Harkins Michelle, Bradfute Steven B
Department of Internal Medicine, Center for Global Health, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, United States of America.
PLoS One. 2025 Jul 8;20(7):e0327698. doi: 10.1371/journal.pone.0327698. eCollection 2025.
While many studies have assessed immune responses to SARS-CoV-2 infection, none have studied functional antibody responses before and after vaccination of exposed patients in New Mexico in the United States. Here, we evaluate antibody binding, antibody neutralization, and antibody dependent cell-mediated cytotoxicity (ADCC) responses from convalescent patients between September 2020 and April 2021. Our results indicate that binding, neutralizing, and ADCC titers remained durable over an estimated 4-month period or were boosted by vaccination. Antibody binding titer stability was comparable to that of antibodies against four common viruses. Hispanic and Latino responses were similar to non-Hispanic/Latino responses in this cohort. Overall, these data shed light on functional antibody responses to SARS-CoV-2 in pre-alpha variant waves in New Mexico.
虽然许多研究评估了对SARS-CoV-2感染的免疫反应，但在美国新墨西哥州，尚无研究对暴露患者接种疫苗前后的功能性抗体反应进行研究。在此，我们评估了2020年9月至2021年4月期间康复患者的抗体结合、抗体中和及抗体依赖性细胞介导的细胞毒性（ADCC）反应。我们的结果表明，结合、中和及ADCC滴度在大约4个月的时间内保持持久，或通过接种疫苗得到增强。抗体结合滴度稳定性与针对四种常见病毒的抗体相当。在该队列中，西班牙裔和拉丁裔的反应与非西班牙裔/拉丁裔的反应相似。总体而言，这些数据揭示了新墨西哥州在阿尔法变体出现之前的浪潮中对SARS-CoV-2的功能性抗体反应。
