美国成年人膳食炎症指数与血清 Klotho 浓度的关系。
Association between Dietary Inflammatory Index and serum Klotho concentration among adults in the United States.
机构信息
Department of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Chengdu, 610041, Sichuan Province, People's Republic of China.
National Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China.
出版信息
BMC Geriatr. 2022 Jun 27;22(1):528. doi: 10.1186/s12877-022-03228-8.
BACKGROUND
Klotho is a hormone that emerges as an antiaging biomarker. However, the influence of the dietary pattern's inflammatory potential on serum Klotho levels in human populations, especially in a general adult population, remains unknown. This study aimed to evaluate the relationship between the dietary inflammatory index (DII) and serum Klotho concentrations in individuals living in the United States. METHODS : From the 2007-2016 National Health and Nutrition Examination Survey database, data of participants who completed the full 24-h dietary history and underwent serum Klotho testing were analyzed. The association between DII and serum Klotho concentrations was estimated using multivariable linear regression models. We also conducted segmented regression model to examine the threshold effect of DII on serum Klotho concentrations.
RESULTS
A total of 10,928 participants were included, with a median serum Klotho concentration of 805.20 pg/mL (IQR: 657.58 - 1001.12) and a median DII of 1.43 (IQR: - 0.16 - 2.82). Multivariable regression showed that participants with high DII scores were associated with low serum Klotho concentrations; when classifying DII into quartiles, after full adjustment, participants in DII quartiles 3 and 4 showed a decrease in Klotho levels (25.27 and 12.44 pg/ml, respectively) compared with those in the lowest quartile (quartile 1) (95% CI: - 41.80, - 8.73 and - 29.83, 4.95, respectively; P for trend = 0.036). The segmented regression showed that the turning point value of DII was - 1.82 (95% CI: - 2.32, - 0.80). A 1-unit increase in DII was significantly associated with lower Klotho levels by - 33.05 (95% CI: - 52.84, - 13.27; P = 0.001) when DII ranges from - 5.18 to - 1.82; however, the relationship was not significant when DII ranges from - 1.82 to 5.42 (P > 0.05). Furthermore, stratified analyses indicated that the observed associations between DII and serum Klotho concentration were stronger among those aged ≥ 56 years, those with normal weight, and those without chronic kidney disease (P for interaction = 0.003, 0.015, and 0.041, respectively).
CONCLUSIONS
In summary, we indicated that there was a dose-response relationship between DII and serum Klotho concentrations, suggesting that adhering to an anti-inflammatory diet has beneficial effects on aging and health by increasing the serum Klotho concentration.
背景
Klotho 是一种抗衰老生物标志物。然而，饮食模式的炎症潜力对人类，特别是普通成年人群体血清 Klotho 水平的影响仍不清楚。本研究旨在评估美国人群中饮食炎症指数（DII）与血清 Klotho 浓度之间的关系。
方法
从 2007-2016 年全国健康与营养调查数据库中，分析了完成完整 24 小时饮食史和接受血清 Klotho 检测的参与者的数据。使用多变量线性回归模型估计 DII 与血清 Klotho 浓度之间的关联。我们还进行了分段回归模型，以检验 DII 对血清 Klotho 浓度的阈值效应。
结果
共纳入 10928 名参与者，中位血清 Klotho 浓度为 805.20 pg/mL（IQR：657.58-1001.12），中位 DII 为 1.43（IQR：-0.16-2.82）。多变量回归显示，DII 评分较高的参与者与低血清 Klotho 浓度相关；当将 DII 分为四分位时，在充分调整后，DII 四分位 3 和 4 的参与者 Klotho 水平下降（分别为 25.27 和 12.44 pg/ml），与四分位 1（最低四分位）相比（95%CI：-41.80，-8.73 和-29.83，4.95，分别；P 趋势=0.036）。分段回归显示，DII 的转折点值为-1.82（95%CI：-2.32，-0.80）。DII 每增加 1 个单位，与 Klotho 水平的相关性就会显著降低-33.05（95%CI：-52.84，-13.27；P=0.001），当 DII 范围在-5.18 至-1.82 之间；然而，当 DII 范围在-1.82 至 5.42 之间时，这种关系并不显著（P>0.05）。此外，分层分析表明，在年龄≥56 岁、体重正常和无慢性肾脏病的参与者中，DII 与血清 Klotho 浓度之间的观察到的相关性更强（P 交互=0.003、0.015 和 0.041）。
结论
总之，我们表明 DII 与血清 Klotho 浓度之间存在剂量反应关系，这表明通过增加血清 Klotho 浓度，坚持抗炎饮食对衰老和健康具有有益影响。
Zotero 插件