Changchun University of Chinese Medicine, Changchun, Jilin, China.
Changchun Medical College, Changchun, Jilin, China.
BMC Endocr Disord. 2022 Jun 27;22(1):165. doi: 10.1186/s12902-022-01080-w.
The present study investigated the prevalence of osteoporosis (OP) among patients with essential hypertension (EH) in the Changchun community and analysed the correlation between EH and OP.
The study included 425 subjects with EH and 425 age- and sex-matched healthy controls. Bone mineral density (BMD) and serum creatinine (CR) levels were measured, and the subjects' current EH and OP statuses were surveyed to analyse the correlation between EH and OP.
The EH group exhibited lower BMD and a higher rate of having OP than the control group, and this difference was statistically significant (p < 0.05). A significant sex difference in the BMD T-score was observed among the subjects (male: - 1.19 ± 1.55, female: - 1.70 ± 1.34). In both the EH group and the control group, the rate of having OP in females was greater than that in males. However, the OP prevalence among subjects with EH varied significantly by age, body weight, fracture history, nocturnal urination frequency, depression and anxiety status, duration of hypertension, and antihypertensive medication use (p < 0.05). Two-way analysis of variance suggested an effect of the interaction between different EH statuses and bone mass conditions on the serum CR values (F = 3.584, p = 0.028, bias η = 0.008).
The prevalence of OP and low BMD were significantly higher among subjects with EH than among healthy controls. Additionally, the findings indicate that age, weight, fracture history, nocturnal urination frequency, depression and anxiety, duration of hypertension and antihypertensive drug use may be correlated to having OP in EH subjects, requiring further studies. Moreover, serum CR levels in subjects with different bone mass profiles were strongly influenced by the presence or absence of EH, and the serum CR levels differed significantly with the interaction of these two factors.
本研究调查了长春社区原发性高血压（EH）患者中骨质疏松症（OP）的患病率，并分析了 EH 与 OP 的相关性。
本研究纳入 425 例 EH 患者和 425 例年龄和性别匹配的健康对照者。测量骨矿物质密度（BMD）和血清肌酐（CR）水平，并调查受试者目前的 EH 和 OP 状况，以分析 EH 与 OP 之间的相关性。
EH 组的 BMD 低于对照组，OP 发生率高于对照组，差异有统计学意义（p<0.05）。受试者的 BMD T 评分存在显著的性别差异（男性：-1.19±1.55，女性：-1.70±1.34）。EH 组和对照组中，女性的 OP 发生率均高于男性。然而，EH 患者的 OP 患病率因年龄、体重、骨折史、夜间排尿次数、抑郁和焦虑状态、高血压持续时间以及降压药物使用而异（p<0.05）。双因素方差分析表明，不同 EH 状态和骨量状况之间的相互作用对血清 CR 值有影响（F=3.584，p=0.028，偏η=0.008）。
EH 患者的 OP 和低 BMD 发生率明显高于健康对照者。此外，研究结果表明，年龄、体重、骨折史、夜间排尿次数、抑郁和焦虑、高血压持续时间和降压药物使用可能与 EH 患者的 OP 相关，需要进一步研究。此外，不同骨量患者的血清 CR 水平受 EH 存在与否的强烈影响，且血清 CR 水平随这两个因素的相互作用而显著不同。
