Xu Dian, Xu Zexian, Cheng Lidi, Gao Xiaohan, Sun Jian, Chen Liqiang
The Affiliated Hospital of Qingdao University, Qingdao, 266003, China.
School of Stomatology, Qingdao University, Qingdao, 266003, China.
Heliyon. 2022 Jun 17;8(6):e09748. doi: 10.1016/j.heliyon.2022.e09748. eCollection 2022 Jun.
Porous bone scaffolds based on high-precision 3D printing technology gave recently been developed for use in bone defect repair. However, conventional scaffold materials have poor mechanical properties and low osteogenic activity, limiting their clinical use. In this study, a porous composite tissue-engineered bone scaffold was prepared using polylactic acid, nano-hydroxyapatite, and nano-magnesium oxide as raw materials for high-precision 3D printing. The composite scaffold takes full advantage of the personalized manufacturing features of 3D printers and can be used to repair complex bone defects in clinical settings. The composite scaffold combines the advantages of nano-hydroxyapatite, which improves the formability of scaffold printing, and of nano-magnesium oxide, which regulates pH during degradation and provide a good environment for cell growth. Additionally, nano-magnesium oxide and nano-hydroxyapatite have a bidirectional effect on promoting the compressive strength and osteogenic activity of the scaffolds. The prepared composite porous scaffolds based on 3D printing technology show promise for bone defect repair.
基于高精度3D打印技术的多孔骨支架最近已被开发用于骨缺损修复。然而，传统的支架材料机械性能差且成骨活性低，限制了它们的临床应用。在本研究中，以聚乳酸、纳米羟基磷灰石和纳米氧化镁为原料，采用高精度3D打印制备了一种多孔复合组织工程骨支架。该复合支架充分利用了3D打印机的个性化制造特点，可用于临床修复复杂的骨缺损。该复合支架结合了纳米羟基磷灰石的优势，其提高了支架打印的成型性，以及纳米氧化镁的优势，其在降解过程中调节pH值并为细胞生长提供良好的环境。此外，纳米氧化镁和纳米羟基磷灰石对提高支架的抗压强度和成骨活性具有双向作用。基于3D打印技术制备的复合多孔支架在骨缺损修复方面显示出前景。
