Zhan Longwen, Zhou Yigui, Liu Ruitang, Sun Ruilong, Li Yunfei, Tian Yongzheng, Fan Bo
Orthopedic Centre-Spine Surgery, The 940 Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, 730050, China.
First Clinical Medical College, Gansu University of Chinese Medicine, Lanzhou, 730000, China.
Biomed Eng Online. 2025 Feb 7;24(1):14. doi: 10.1186/s12938-025-01346-z.
Currently, bone tissue engineering is a research hotspot in the treatment of orthopedic diseases, and many problems in orthopedics can be solved through bone tissue engineering, which can be used to treat fractures, bone defects, arthritis, etc. More importantly, it can provide an alternative to traditional bone grafting and solve the problems of insufficient autologous bone grafting, poor histocompatibility of grafts, and insufficient induced bone regeneration. Growth factors are key factors in bone tissue engineering by promoting osteoblast proliferation and differentiation, which in turn increases the efficiency of osteogenesis and bone regeneration. 3D printing technology can provide carriers with better pore structure for growth factors to improve the stability of growth factors and precisely control their release. Studies have shown that 3D-printed scaffolds containing growth factors provide a better choice for personalized treatment, bone defect repair, and bone regeneration in orthopedics, which are important for the treatment of orthopedic diseases and have potential research value in orthopedic applications. This paper aims to summarize the research progress of 3D printed scaffolds containing growth factors in orthopedics in recent years and summarize the use of different growth factors in 3D scaffolds, including bone morphogenetic proteins, platelet-derived growth factors, transforming growth factors, vascular endothelial growth factors, etc. Optimization of material selection and the way of combining growth factors with scaffolds are also discussed.
目前，骨组织工程是骨科疾病治疗中的一个研究热点，骨科领域的许多问题都可以通过骨组织工程来解决，其可用于治疗骨折、骨缺损、关节炎等。更重要的是，它可以为传统骨移植提供一种替代方法，并解决自体骨移植不足、移植物组织相容性差以及诱导骨再生不足等问题。生长因子是骨组织工程中的关键因素，通过促进成骨细胞增殖和分化，进而提高成骨和骨再生效率。3D打印技术可为生长因子提供具有更好孔隙结构的载体，以提高生长因子的稳定性并精确控制其释放。研究表明，含有生长因子的3D打印支架为骨科个性化治疗、骨缺损修复和骨再生提供了更好的选择，这对骨科疾病的治疗具有重要意义，在骨科应用中具有潜在的研究价值。本文旨在总结近年来含生长因子的3D打印支架在骨科领域的研究进展，并概述不同生长因子在3D支架中的应用，包括骨形态发生蛋白、血小板衍生生长因子、转化生长因子、血管内皮生长因子等。还讨论了材料选择的优化以及生长因子与支架结合的方式。
