Liu Zhijian, Chen Li, Sun Feng, Lv Bingxin, Ge Xiaolong, Shao Lihua, Liu Song
Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China.
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Nutr Cancer. 2022;74(10):3574-3581. doi: 10.1080/01635581.2022.2083190. Epub 2022 Jun 28.
Postoperative complications of gastrectomy for gastric cancer affect the efficacy of surgery. It is of clinical significance to identify high-risk patients with postoperative complications as early as possible. A total of 206 patients who underwent gastrectomy were enrolled in this study. Univariate and multivariate analyses were used to determine the risk factors for postoperative complications. The cutoff value and diagnostic accuracy of the C-reactive protein/albumin ratio were calculated by receiver operating characteristic curves. A total of 64 (31.1%) patients developed postoperative complications. Multivariate analysis confirmed that the C-reactive protein/albumin ratio on the first day after operation was an independent risk factor for postoperative complications (OR = 2.538, 95%CI: 1.346-4.785, = 0.004). The cutoff value of the C-reactive protein/albumin ratio on the first day after operation was 2.105 calculated by receiver operating characteristic curves. Patients with a C-reactive protein/albumin ratio greater than 2.105 had a higher incidence of postoperative complications (43.2% vs 22.0%, = 0.001) and longer postoperative hospital stay (15.3 ± 1.2 vs 13.0 ± 0.5, = 0.042) than patients with less than 2.105. Patients with C-reactive protein/albumin ratio greater than 2.105 on the first day after operation are more likely to have postoperative complications.
胃癌胃切除术后的并发症会影响手术疗效。尽早识别术后并发症的高危患者具有临床意义。本研究共纳入206例行胃切除术的患者。采用单因素和多因素分析来确定术后并发症的危险因素。通过受试者工作特征曲线计算C反应蛋白/白蛋白比值的临界值和诊断准确性。共有64例(31.1%)患者发生术后并发症。多因素分析证实,术后第1天的C反应蛋白/白蛋白比值是术后并发症的独立危险因素(OR = 2.538,95%CI:1.346 - 4.785,P = 0.004)。通过受试者工作特征曲线计算得出术后第1天C反应蛋白/白蛋白比值的临界值为2.105。C反应蛋白/白蛋白比值大于2.105的患者术后并发症发生率更高(43.2%对22.0%,P = 0.001),术后住院时间更长(15.3±1.2对13.0±0.5,P = 0.042),高于比值小于2.105的患者。术后第1天C反应蛋白/白蛋白比值大于2.105的患者更易发生术后并发症。