饮酒与血液中DNA甲基化之间的关联：观察性研究的系统评价
Association between alcohol consumption and DNA methylation in blood: a systematic review of observational studies.
作者信息
Dragic Dzevka, Chang Sue-Ling, Ennour-Idrissi Kaoutar, Durocher Francine, Severi Gianluca, Diorio Caroline
机构信息
Department of Social & Preventive Medicine, Faculty of Medicine, Université Laval, Quebec, QC, G1V 0A6, Canada.
Cancer Research Center, CHU de Québec Research Center, Oncology division, Quebec, QC, G1R 3S3, Canada.
出版信息
Epigenomics. 2022 Jun;14(12):793-810. doi: 10.2217/epi-2022-0055. Epub 2022 Jun 28.
We systematically reviewed and evaluated current literature on alcohol consumption and DNA methylation (DNAm) at the genome-wide and probe-wise level in blood of adults. Five databases (PubMed, Embase, Web of Science, CINAHL and PsycInfo) were searched until 20 December 2020. Studies assessing the effect of alcohol dependence on DNAm were not eligible. 11 cross-sectional studies were included with 88 to 9643 participants. Overall, all studies had a risk of bias criteria unclear or unmet. Epigenome-wide association studies identified between 0 and 5458 differentially methylated positions, and 15 were observed in at least four studies. Potential methylation markers for alcohol consumption have been identified, but further validation in large cohorts is needed.
我们在全基因组和探针水平上系统地回顾和评估了关于成年人血液中酒精消费与DNA甲基化（DNAm）的当前文献。检索了五个数据库（PubMed、Embase、Web of Science、CINAHL和PsycInfo），直至2020年12月20日。评估酒精依赖对DNAm影响的研究不符合要求。纳入了11项横断面研究，参与者为88至9643人。总体而言，所有研究的偏倚风险标准均不明确或未得到满足。全表观基因组关联研究确定了0至5458个差异甲基化位点，其中15个在至少四项研究中被观察到。已确定了酒精消费的潜在甲基化标志物，但需要在大型队列中进一步验证。
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