Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Research Fellow of Japan Society for the Promotion of Science, Kojimachi Business Center Building, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo 102-0083, Japan.
Biomater Sci. 2022 Jul 26;10(15):4077-4094. doi: 10.1039/d2bm00497f.
Layer-by-layer (LbL) assembly has attracted much interest because of its ability to provide nanoscale control over film characteristics and because of a wide choice of available materials. The methods of LbL not only determine the process properties, but also directly affect film properties. In this review, we will discuss LbL methodologies that have been used in biomedical fields. Special attention is devoted to different properties arising from methods that allow for diverse biomedical applications, ranging from surface modification to tissue engineering. We conclude with a discussion of the current challenges and future perspectives.
层层组装（LbL）因其能够对薄膜特性进行纳米级控制以及可选择的广泛材料而受到广泛关注。LbL 的方法不仅决定了工艺性能，而且直接影响薄膜性能。在本综述中，我们将讨论已在生物医学领域中使用的 LbL 方法。特别关注的是，允许各种生物医学应用的方法所产生的不同性质，从表面修饰到组织工程。最后，我们讨论了当前的挑战和未来的展望。
