遗传和压力因素对西班牙裔/拉丁裔人群中高血压患病率的影响：西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）。

Genetic and stress influences on the prevalence of hypertension among hispanics/latinos in the hispanic community health study/study of latinos (HCHS/SOL).

机构信息

University of Miami, Department of Psychology, Coral Gables, USA.

UNC-Chapel Hill, Department of Epidemiology, Chapel Hill, USA.

出版信息

Blood Press. 2022 Dec;31(1):155-163. doi: 10.1080/08037051.2022.2091977.

DOI:10.1080/08037051.2022.2091977

PMID:35762607

Abstract

PURPOSE

The current study examined the effects of chronic stress and a genetic risk score on the presence of hypertension and elevated systolic blood pressure and diastolic blood pressure among Hispanics/Latinos in the target population of Hispanic Community Health Study/Study of Latinos.

MATERIALS AND METHODS

Of the participants ( = 11,623) assessed during two clinic visits (Visit 1 2008-2013 & Visit 2 2014-2018), we analysed data from 7,429 adults (50.4% female), aged 18-74, who were genotyped and responded to chronic stress questionnaires. We calculated an unweighted genetic risk score using blood pressure increasing single nucleotide polymorphisms (SNPs) found to be generalisable to Hispanics/Latinos (10 SNPs). Linear and logistic regression models were used to estimate associations between chronic stress and genetic risk score and their interaction, with prevalent Visit 2 SBP or DBP, and hypertension, respectively. Models accounted for sampling weights, stratification, and cluster design.

RESULTS

Chronic stress (adjusted OR = 1.18, 95%CI:1.15,1.22) and hypertension genetic risk score (adjusted OR = 1.04, 95%CI:1.01,1.07) were significantly associated with prevalent hypertension, but there was no significant interaction between the chronic stress and genetic risk score on hypertension ( = .49). genetic risk score ( = .32, 95%CI:.08, .55, = .02) and chronic stress ( = .45, 95%CI:.19, .72, = .11) were related to DBP, with no significant interaction ( = .62). Genetic risk score ( = .42, 95%CI:.08, .76, = .01) and chronic stress ( = .80, 95%CI:.34,1.26, = .11) were also related to SBP, with no significant interaction ( = .51).

CONCLUSION

Results demonstrate the utility of a genetic risk score for blood pressure and are consistent with literature suggesting chronic stress has a strong, direct association with elevated blood pressure among U.S. Hispanics/Latinos.

摘要

目的

本研究考察了慢性应激和遗传风险评分对目标人群西班牙裔社区健康研究/拉丁裔研究中西班牙裔/拉丁裔人群高血压和收缩压及舒张压升高的影响。

材料和方法

在两次就诊（2008-2013 年就诊 1 和 2014-2018 年就诊 2）期间评估的参与者中（ = 11,623），我们分析了来自 7,429 名年龄在 18-74 岁、接受基因分型且对慢性应激问卷做出回应的成年人的数据。我们使用在西班牙裔/拉丁裔人群中具有可推广性的血压升高单核苷酸多态性（SNP）计算了未加权的遗传风险评分（10 个 SNP）。线性和逻辑回归模型用于估计慢性应激和遗传风险评分及其相互作用与就诊 2 收缩压或舒张压及高血压的相关性。模型考虑了抽样权重、分层和聚类设计。

结果

慢性应激（调整后的 OR=1.18，95%CI：1.15，1.22）和高血压遗传风险评分（调整后的 OR=1.04，95%CI：1.01，1.07）与高血压显著相关，但慢性应激和遗传风险评分在高血压方面没有显著的相互作用（ = .49）。遗传风险评分（ = .32，95%CI：.08，.55， = .02）和慢性应激（ = .45，95%CI：.19，.72， = .11）与舒张压相关，且相互作用不显著（ = .62）。遗传风险评分（ = .42，95%CI：.08，.76， = .01）和慢性应激（ = .80，95%CI：.34，1.26， = .11）与收缩压也相关，且相互作用不显著（ = .51）。