Rao Hridya, Weiss Margaret C, Moon Jee Young, Perreira Krista M, Daviglus Martha L, Kaplan Robert, North Kari E, Argos Maria, Fernández-Rhodes Lindsay, Sofer Tamar
Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA.
Department of Epidemiology and Biostatistics, School of Public Health, University of Illinois Chicago, Chicago, IL, USA.
HGG Adv. 2025 Jan 9;6(1):100376. doi: 10.1016/j.xhgg.2024.100376. Epub 2024 Oct 29.
The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) is a multicenter, longitudinal cohort study designed to evaluate environmental, lifestyle, and genetic risk factors as they relate to cardiometabolic and other chronic diseases among Hispanic/Latino populations in the United States. Since the study's inception in 2008, as a result of the study's robust genetic measures, HCHS/SOL has facilitated major contributions to the field of genetic research. This 10-year retrospective review highlights the major findings for genotype-phenotype relationships and advancements in statistical methods owing to the HCHS/SOL. Furthermore, we discuss the ethical and societal challenges of genetic research, especially among Hispanic/Latino adults in the United States. Continued genetic research, ancillary study expansion, and consortia collaboration through HCHS/SOL will further drive knowledge and advancements in human genetics research.
西班牙裔社区健康研究/拉丁裔研究（HCHS/SOL）是一项多中心纵向队列研究，旨在评估与美国西班牙裔/拉丁裔人群心脏代谢及其他慢性病相关的环境、生活方式和遗传风险因素。自2008年该研究启动以来，由于其强大的基因检测手段，HCHS/SOL为基因研究领域做出了重大贡献。这项为期10年的回顾性综述突出了HCHS/SOL在基因型-表型关系及统计方法进展方面的主要发现。此外，我们还讨论了基因研究面临的伦理和社会挑战，尤其是在美国西班牙裔/拉丁裔成年人中。通过HCHS/SOL持续开展基因研究、扩大辅助研究以及进行联盟合作，将进一步推动人类基因研究的知识积累和进步。
