缅甸产 NDM 型金属β-内酰胺酶的耐碳青霉烯类肺炎克雷伯菌临床分离株的传播。
Spread of Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates Producing NDM-Type Metallo-β-Lactamase in Myanmar.
机构信息
Department of Clinical Laboratory, Juntendo Universitygrid.258269.2grid.411966.dgrid.258269.2 Hospital, Tokyo, Japan.
Department of Clinical Laboratory Medicine, Juntendo Universitygrid.258269.2grid.411966.dgrid.258269.2 Graduate School of Medicine, Tokyo, Japan.
出版信息
Microbiol Spectr. 2022 Aug 31;10(4):e0067322. doi: 10.1128/spectrum.00673-22. Epub 2022 Jun 28.
A total of 38 isolates of carbapenem-resistant Klebsiella pneumoniae harboring were obtained during surveillance of 10 hospitals in Myanmar. Of these 38 isolates, 19 (50%) harbored genes encoding 16S rRNA methylases, such as or . The K. pneumoniae strains tested belonged to 17 sequence types (STs), including the high-risk clonal lineages ST101 and ST147. The ST101 and ST147 isolates carried IncFII plasmids harboring and IncFIB(pQil) plasmids harboring , respectively. These results indicate that IncFII plasmids harboring and IncFIB(pQil) plasmids harboring have been spreading in K. pneumoniae ST101 and ST147 isolates, respectively, in Myanmar. The emergence of carbapenem-resistant K. pneumoniae has become a serious problem in medical settings worldwide. The present study demonstrated that carbapenem-resistant K. pneumoniae strains have been spreading in medical settings in Myanmar. In particular, plasmid genes encoding NDMs and 16S rRNA methylases have been spreading in K. pneumoniae high-risk clones.
在对缅甸 10 家医院进行监测期间，共获得了 38 株携带 的耐碳青霉烯肺炎克雷伯菌。在这 38 株分离株中，有 19 株（50%）携带编码 16S rRNA 甲基化酶的基因，如 或 。测试的肺炎克雷伯菌菌株属于 17 种序列类型（STs），包括高风险克隆谱系 ST101 和 ST147。ST101 和 ST147 分离株携带 IncFII 质粒，携带 ，IncFIB(pQil) 质粒携带 。这些结果表明，在缅甸，携带 的 IncFII 质粒和携带 的 IncFIB(pQil) 质粒分别在 ST101 和 ST147 肺炎克雷伯菌分离株中传播。碳青霉烯类耐药肺炎克雷伯菌的出现已成为全球医疗环境中的一个严重问题。本研究表明，耐碳青霉烯肺炎克雷伯菌菌株已在缅甸的医疗环境中传播。特别是，携带 NDMs 和 16S rRNA 甲基化酶的质粒基因在肺炎克雷伯菌高危克隆中传播。
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