Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan.
Department of Microbiome Research, Juntendo University School of Medicine, Tokyo, Japan.
mSphere. 2020 Mar 11;5(2):e00054-20. doi: 10.1128/mSphere.00054-20.
Surveillance of 10 hospitals and a regional public health laboratory in Myanmar identified 31 isolates of carbapenem-resistant complex harboring Of these isolates, 19 were highly resistant to aminoglycosides and harbored one or more genes encoding 16S rRNA methylases, including , , , and/or Of the 19 isolates, 16 were ST200, with on the chromosome and a plasmid harboring and , indicating that these isolates were clonally disseminated nationwide in Myanmar. The emergence of multidrug-resistant complex has become a public health threat worldwide. is a recently classified species belonging to complex. Here, we report a clonal dissemination of multidrug-resistant ST200 producing two types of New Delhi metallo-β-lactamase (NDM-type MBL), NDM-1 and -4, and three types of 16S rRNA methylases, ArmA, RmtC, and RmtE, in hospitals in Myanmar. The observation of these multidrug-resistant ST200 isolates stresses the urgency to continue molecular epidemiological surveillance of these pathogens in Myanmar and in South Asian countries.
在缅甸的 10 家医院和一个地区公共卫生实验室进行监测，鉴定出 31 株携带碳青霉烯酶耐药复合物的分离株。在这些分离株中，有 19 株对氨基糖苷类药物高度耐药，并携带一个或多个编码 16S rRNA 甲基化酶的基因，包括、、、和/或。在 19 株分离株中，有 16 株为 ST200，染色体上有，质粒上携带和，表明这些分离株在缅甸全国范围内克隆传播。多药耐药 复合的出现已成为全球公共卫生威胁。 是最近分类的属于 复合的物种。在这里，我们报告了在缅甸医院中，两种类型的新德里金属β-内酰胺酶（NDM 型 MBL），NDM-1 和 -4，以及三种类型的 16S rRNA 甲基化酶，ArmA、RmtC 和 RmtE，产生两种类型的多药耐药 ST200 的克隆传播。这些多药耐药 ST200 分离株的观察强调了在缅甸和南亚国家继续对这些病原体进行分子流行病学监测的紧迫性。
