Lukehart S A
Southeast Asian J Trop Med Public Health. 1986 Dec;17(4 Suppl):78-83.
Recent advances in treponemal research have increased our understanding of the pathogenesis and host response to treponemal infection was well as the antigenic structure of the pathogenic and nonpathogenic treponemes. Although these new methodologies are currently limited to research laboratories, the new findings may ultimately have practical applications to the control of the treponematoses. It is reasonable to expect that reagents for the identification of pathogenic treponemes (vs. non-pathogens) will be commercially available in the next three years. The field application of these reagents may be limited and specimens may need to be sent to regional or reference laboratories for evaluation. Similarly, the detection of specific treponemal IgM antibody may be limited to regional or reference laboratories. This does not preclude the utility of these tests, however, in epidemiologic surveys for determination of disease prevalence before and after treatment programmes, such surveys comprise the heart of any disease control programme.
梅毒螺旋体研究的最新进展增进了我们对梅毒螺旋体感染的发病机制、宿主反应以及致病性和非致病性梅毒螺旋体抗原结构的理解。尽管这些新方法目前仅限于研究实验室，但新发现最终可能在梅毒防治中具有实际应用价值。预计在未来三年内将有用于鉴定致病性梅毒螺旋体（与非致病性梅毒螺旋体相对）的试剂上市。这些试剂的现场应用可能有限，标本可能需要送往区域或参考实验室进行评估。同样，特异性梅毒螺旋体IgM抗体的检测可能也仅限于区域或参考实验室。然而，这并不排除这些检测在治疗项目前后疾病患病率测定的流行病学调查中的效用，此类调查是任何疾病控制项目的核心。
