Taylor C R
J Histochem Cytochem. 1978 Jul;26(7):496-512. doi: 10.1177/26.7.357639.
The diagnosis and classification of malignant lymphomas is based upon traditional histological criteria evolved over the years by successive generations of pathologists. Immunoperoxidase methods applied to formalin paraffin sections have permitted a direct correlation of these established morphologic criteria with newer immunological concepts of the form and function of the B lymphocyte and its derivatives. Study of material from 500 cases of Hodgkin's disease, non-Hodgkin lymphomas, and myeloma has revealed that many of these conditions may find a common origin in the lymphocyte, and that some malignant cells, previously identified as malignant histiocytes or reticulum cells are rather related to or derived from the transformed lymphocyte or immunoblast. The corresponding tumors are thus more logically designated immunoblastic sarcoma. The study also reveals a claser developmental relationship between multiple myeloma and immunoblastic sarcoma than previously suspected, and suggests that all of the B cell lymphomas occur as part of a continuous spectrum of disease, rather than as separate entities as implied by current histological classifications. The study of immunoglobulin in formalin paraffin sections is illustrative of the great potential of this method in the diagnosis and study of neoplasia in general.
恶性淋巴瘤的诊断和分类基于历代病理学家多年来逐步形成的传统组织学标准。应用于福尔马林石蜡切片的免疫过氧化物酶方法，使这些既定的形态学标准与B淋巴细胞及其衍生物的形态和功能的新免疫学概念直接关联起来。对500例霍奇金病、非霍奇金淋巴瘤和骨髓瘤病例材料的研究表明，这些疾病中的许多可能起源于淋巴细胞，并且一些先前被鉴定为恶性组织细胞或网状细胞的恶性细胞，实际上与转化的淋巴细胞或免疫母细胞有关或源自它们。因此，相应的肿瘤更合理地被命名为免疫母细胞肉瘤。该研究还揭示了多发性骨髓瘤与免疫母细胞肉瘤之间的发育关系比以前认为的更为紧密，并表明所有B细胞淋巴瘤都是作为疾病的连续谱的一部分出现，而不是像当前组织学分类所暗示的那样是独立的实体。对福尔马林石蜡切片中免疫球蛋白的研究说明了该方法在肿瘤诊断和一般研究中的巨大潜力。
