Jinan Mingshui Eye Hospital, Number 5601, Longquan Road, Zhangqiu District, 250200, Jinan, China.
Tianjin Key Laboratory of Ophthalmology and Visual Science, Tianjin Eye Hospital, Clinical College of Ophthalmology, Tianjin Medical University, Tianjin, China.
BMC Ophthalmol. 2022 Jun 29;22(1):286. doi: 10.1186/s12886-022-02454-3.
To evaluate corneal densitometry after allogeneic corneal small-incision intrastromal lenticule implantation (SILI) for hyperopia.
A retrospective study. Thirty-one hyperopic eyes of 24 patients who underwent SILI were enrolled in this study. Examinations took place preoperatively and 1 week, 1 month, 3 months, and 6 months postoperatively. Corneal densitometry (CD) from different concentric radial zones (0-2, 2-6, and 6-10 mm annulus) and layers (anterior, central, and posterior) were obtained using Scheimpflug imaging. The association between CD changes and the uncorrected distance visual acuity (UDVA), spherical equivalent (SE), central corneal thickness (CCT) and K value were examined.
No serious intraoperative complications occurred during SILI. The mean total CD increased postoperatively compared to preoperatively (P < 0.01). However, no significant differences were found among the four subsequent follow-up time points (P > 0.05). At 6 months postoperatively, the CD values showed an increase of 2.71 ± 2.52, 2.23 ± 2.25, and 1.87 ± 2.46 at the 0-2, 2-6, and 6-10 mm annuli, respectively (all at P < 0.01). The anterior 120 μm displayed the highest densitometry before and after surgery (all at P < 0.01). No significant increase was found within the posterior 60 μm of the cornea (P > 0.05). No correlation was found between the CD and relevant parameters(all at P > 0.05).
SILI resulted in an increase in CD within the surgically altered area, however such change has no significant correlation with visual outcomes.
评估同种异体角膜小切口基质内透镜植入术（SILI）治疗远视术后的角膜密度。
回顾性研究。本研究纳入 24 名患者的 31 只远视眼，均接受 SILI 治疗。术前及术后 1 周、1 个月、3 个月和 6 个月进行检查。使用 Scheimpflug 成像获得不同同心放射状区域（0-2、2-6 和 6-10mm 环）和层（前、中、后）的角膜密度（CD）。检查 CD 变化与未矫正远视力（UDVA）、等效球镜（SE）、中央角膜厚度（CCT）和 K 值之间的关系。
SILI 术中无严重并发症。与术前相比，术后总 CD 增加（P<0.01）。然而，在随后的四个随访时间点之间，差异无统计学意义（P>0.05）。术后 6 个月，0-2、2-6 和 6-10mm 环的 CD 值分别增加了 2.71±2.52、2.23±2.25 和 1.87±2.46（均 P<0.01）。手术前后角膜前 120μm 密度最高（均 P<0.01）。角膜后 60μm 内未见明显增加（P>0.05）。CD 与相关参数之间无相关性（均 P>0.05）。
SILI 导致手术改变区域内的 CD 增加，但这种变化与视力结果无显著相关性。
