Department of Medical Imaging, 562122The Affiliated Hospital of Jining Medical University, Jining, PR China.
Acta Radiol. 2023 Mar;64(3):951-961. doi: 10.1177/02841851221107626. Epub 2022 Jun 28.
Non-invasive imaging technologies for assessing axillary lymph node (ALN) metastasis of breast cancer are needed in clinical practice.
To explore the clinical value of intravoxel incoherent motion (IVIM) and diffusional kurtosis imaging (DKI) for predicting ALN metastasis of breast cancer.
A total of 194 patients with pathologically confirmed breast cancer who underwent IVIM and DKI examination were reviewed retrospectively. The IVIM derived parameters of D, D*, and and DKI-derived parameters of MD and MK were measured. The independent samples -test was used to compare the parameters between the ALN metastasis and non-ALN metastasis groups. Receiver operating characteristic (ROC) curve analysis was also performed.
The D and MD in the ALN metastasis group were significantly lower than those in the non-ALN metastasis group (< 0.001, < 0.001). The D*, , and MK were higher in the ALN metastasis group than in the non-ALN metastasis group ( = 0.015, 0.014, and 0.001, respectively). The area under the ROC curve (AUC) of D (0.768) was highest. In addition, the diagnostic efficiency of both IVIM and DKI were higher than that of the conventional MRI ( = 0.002, = 0.048). The diagnostic efficiency of IVIM + DKI were higher than that of the IVIM or DKI alone ( = 0.021, = 0.004).
IVIM and DKI can be used for predicting breast cancer ALN metastasis with D as the most meaningful parameter.
临床上需要非侵入性成像技术来评估乳腺癌腋窝淋巴结（ALN）转移。
探讨体素内不相干运动（IVIM）和弥散峰度成像（DKI）预测乳腺癌 ALN 转移的临床价值。
回顾性分析了 194 例经病理证实的乳腺癌患者的 IVIM 和 DKI 检查资料。测量 IVIM 衍生的 D、D*、和 以及 DKI 衍生的 MD 和 MK 参数。采用独立样本 t 检验比较 ALN 转移组与非 ALN 转移组之间的参数。还进行了受试者工作特征（ROC）曲线分析。
ALN 转移组的 D 和 MD 明显低于非 ALN 转移组（<0.001，<0.001）。ALN 转移组的 D*、、和 MK 高于非 ALN 转移组（=0.015，=0.014，和=0.001）。D 的 ROC 曲线下面积（AUC）最高（0.768）。此外，IVIM 和 DKI 的诊断效能均高于常规 MRI（=0.002，=0.048）。IVIM+DKI 的诊断效能高于 IVIM 或 DKI 单独（=0.021，=0.004）。
IVIM 和 DKI 可用于预测乳腺癌 ALN 转移，D 是最有意义的参数。
