Universidade Federal do Paraná, Departamento de Clínica Cirúrgica - Curitiba - PR - Brazil.
Universidade Federal do Paraná, Departamento de Informática - Curitiba - PR - Brazil.
Arq Bras Cir Dig. 2022 Jun 24;35:e1659. doi: 10.1590/0102-672020210002e1659. eCollection 2022.
The use of probiotics as adjuvants in the treatment of eating disorders, known as psychobiotics, has already been investigated as a means of modulating the microbiota-gut-brain axis. This study aimed to assess the effect of probiotic supplementation on binge eating and food addiction in subjects after Roux-en-Y gastric bypass surgery.
This is a randomized, double-blind, placebo-controlled trial involving 101 patients who received probiotic (Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07) or placebo supplements for 90 days after bariatric surgery, starting on the seventh postoperative day. They were evaluated preoperatively (T0) and postoperatively at 90 days (T1) and 1 year (T2) after surgery. The Yale Food Addiction Scale (YFAS) and Binge Eating Scale (BES) were applied to assess food addiction and binge eating, respectively.
Before surgery, one-third of the patients presented with a food addiction and binge eating diagnosis. The number of symptoms of YFAS and the BES score decreased significantly in both groups at T1 compared to T0. However, a significant effect of treatment with probiotics was observed 1 year after surgery (T2). Both the number of symptoms of food addiction and the binge eating score were lower in the probiotic group than in the placebo group (p=0.037 and p=0.030, respectively).
The use of probiotic supplementation for 90 days in the immediate postoperative period may decrease food addiction symptoms and binge eating score up to 1 year after surgery compared to controls.
将益生菌作为治疗饮食失调的辅助药物（称为心理益生菌），已经被研究用于调节微生物群-肠道-大脑轴。本研究旨在评估益生菌补充剂对 Roux-en-Y 胃旁路手术后患者暴食和食物成瘾的影响。
这是一项随机、双盲、安慰剂对照试验，涉及 101 名患者，他们在接受减肥手术后的第 7 天开始接受益生菌（嗜酸乳杆菌 NCFM 和双歧杆菌 lactis Bi-07）或安慰剂补充剂 90 天。他们在术前（T0）和术后 90 天（T1）和 1 年（T2）进行评估。应用耶鲁食物成瘾量表（YFAS）和暴食量表（BES）分别评估食物成瘾和暴食。
术前，三分之一的患者被诊断为食物成瘾和暴食。与 T0 相比，两组在 T1 时 YFAS 症状数和 BES 评分均显著下降。然而，手术后 1 年（T2）益生菌治疗的效果显著。与安慰剂组相比，益生菌组的食物成瘾症状数和暴食评分均较低（p=0.037 和 p=0.030）。
与对照组相比，在术后即刻期使用益生菌补充剂 90 天可能会降低术后 1 年的食物成瘾症状数和暴食评分。
