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Elevated fibrosis‑4 index is associated with 30-day mortality in adult hemophagocytic lymphohistiocytosis patients.纤维化-4指数升高与成人噬血细胞性淋巴组织细胞增生症患者30天死亡率相关。
Ann Hematol. 2025 Sep 20. doi: 10.1007/s00277-025-06623-4.

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Mendelian Randomization Analysis Reveals No Causal Relationship Between Nonalcoholic Fatty Liver Disease and Severe COVID-19.孟德尔随机化分析显示非酒精性脂肪性肝病与严重 COVID-19 之间不存在因果关系。
Clin Gastroenterol Hepatol. 2022 Jul;20(7):1553-1560.e78. doi: 10.1016/j.cgh.2022.01.045. Epub 2022 Feb 3.
2
Liver Injury and Elevated FIB-4 Define a High-Risk Group in Patients with COVID-19.肝损伤和FIB-4升高界定了COVID-19患者中的高危群体。
J Clin Med. 2021 Dec 28;11(1):153. doi: 10.3390/jcm11010153.
3
Low Accuracy of FIB-4 and NAFLD Fibrosis Scores for Screening for Liver Fibrosis in the Population.人群中 FIB-4 和 NAFLD 纤维化评分对筛查肝纤维化的准确性低。
Clin Gastroenterol Hepatol. 2022 Nov;20(11):2567-2576.e6. doi: 10.1016/j.cgh.2021.12.034. Epub 2021 Dec 29.
4
Liver Fibrosis Index FIB-4 Is Associated With Mortality in COVID-19.肝纤维化指数FIB-4与COVID-19患者的死亡率相关。
Hepatol Commun. 2021 Mar;5(3):434-445. doi: 10.1002/hep4.1650. Epub 2020 Dec 10.
5
Fibrosis-4 Predicts the Need for Mechanical Ventilation in a National Multiethnic Cohort of Corona Virus Disease 2019.纤维化-4评分可预测19例新型冠状病毒肺炎全国多民族队列中机械通气的需求。
Hepatol Commun. 2021 Sep;5(9):1605-1615. doi: 10.1002/hep4.1737. Epub 2021 Jul 16.
6
Possible unrecognised liver injury is associated with mortality in critically ill COVID-19 patients.在危重症COVID-19患者中，潜在的未被识别的肝损伤与死亡率相关。
Therap Adv Gastroenterol. 2021 Jun 14;14:17562848211023410. doi: 10.1177/17562848211023410. eCollection 2021.
7
COVID-19 and liver injury: a meta-analysis.新型冠状病毒肺炎与肝损伤：一项荟萃分析
Eur J Gastroenterol Hepatol. 2021 Jul 1;33(7):990-995. doi: 10.1097/MEG.0000000000001817.
8
SARS-CoV-2 infection of the liver directly contributes to hepatic impairment in patients with COVID-19.SARS-CoV-2 感染肝脏直接导致 COVID-19 患者肝损伤。
J Hepatol. 2020 Oct;73(4):807-816. doi: 10.1016/j.jhep.2020.05.002. Epub 2020 May 11.
9
Risk of severe illness from COVID-19 in patients with metabolic dysfunction-associated fatty liver disease and increased fibrosis scores.代谢功能障碍相关脂肪性肝病且纤维化评分升高的患者感染新型冠状病毒肺炎后出现重症的风险。
Gut. 2020 Aug;69(8):1545-1547. doi: 10.1136/gutjnl-2020-321611. Epub 2020 May 15.
10
COVID-19: Abnormal liver function tests.COVID-19：肝功能异常。
J Hepatol. 2020 Sep;73(3):566-574. doi: 10.1016/j.jhep.2020.04.006. Epub 2020 Apr 13.

Quantitative assessment of fibrosis-4 score and adverse clinical outcomes in patients with COVID-19.

作者信息

Tang Kefu, Wang Lu, Shen Lu, He Lin, Wu Xi

机构信息

Prenatal Diagnosis Center, Department of Clinical Laboratory, Changning Maternity and Infant Health Hospital, East China Normal University, Shanghai, 200051, China.

Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, 200030, China.

出版信息

Sci China Life Sci. 2022 Dec;65(12):2560-2563. doi: 10.1007/s11427-021-2138-7. Epub 2022 Jun 23.

DOI:10.1007/s11427-021-2138-7
PMID:35767206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9244247/
Abstract
摘要