School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
Department of Dermatology, Seoul National University College of Medicine, Seoul National University Bundang Hospital (SNUBH), Seongnam, 13620, Republic of Korea.
Sci Rep. 2022 Jun 29;12(1):10935. doi: 10.1038/s41598-022-15197-4.
Long wavelengths that can deeply penetrate into human skin are required to maximize therapeutic effects. Hence, various studies on near-infrared organic light-emitting diodes (NIR OLEDs) have been conducted, and they have been applied in numerous fields. This paper presents a microcavity tandem NIR OLED with narrow full-width half-maximum (FWHM) (34 nm), high radiant emittance (> 5 mW/cm) and external quantum efficiency (EQE) (19.17%). Only a few papers have reported on biomedical applications using the entire wavelength range of the visible and NIR regions. In particular, no biomedical application studies have been reported in the full wavelength region using OLEDs. Therefore, it is worth researching the therapeutic effects of using OLED, a next-generation light source, and analyzing trends for cell proliferation effects. Cell proliferation effects were observed in certain wavelength regions when B, G, R, and NIR OLEDs were used to irradiate human fibroblasts. The results of an in-vitro experiment indicated that the overall tendency of wavelengths is similar to that of the cytochrome c oxidase absorption spectrum of human fibroblasts. This is the first paper to report trends in the cell proliferation effects in all wavelength regions using OLEDs.
需要能够深入穿透人体皮肤的长波长，以最大限度地提高治疗效果。因此，已经进行了各种近红外有机发光二极管（NIR OLED）的研究，并将其应用于许多领域。本文提出了一种具有窄全宽半最大值（FWHM）（34nm）、高辐射出射度（>5mW/cm）和外量子效率（EQE）（19.17%）的微腔串联 NIR OLED。只有少数几篇论文报道了使用可见光和近红外区域全波长范围的生物医学应用。特别是，没有使用 OLED 报道在全波长范围内的生物医学应用研究。因此，研究使用 OLED 作为下一代光源的治疗效果并分析细胞增殖效果的趋势是值得的。当使用 B、G、R 和 NIR OLED 照射人成纤维细胞时，在某些波长区域观察到了细胞增殖效应。体外实验的结果表明，各波长的总体趋势与人成纤维细胞细胞色素 c 氧化酶吸收光谱相似。这是第一篇使用 OLED 报告所有波长区域细胞增殖效应趋势的论文。
