Lee Ho Seung, Noh Byeongju, Kong Seong Uk, Hwang Yong Ha, Cho Ha-Eun, Jeon Yongmin, Choi Kyung Cheol
School of Electrical Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Republic of Korea.
Department of Biomedical Engineering, Gachon University, Seongnam, Republic of Korea.
Npj Flex Electron. 2023;7(1):15. doi: 10.1038/s41528-023-00248-1. Epub 2023 Mar 17.
Increasing demand for real-time healthcare monitoring is leading to advances in thin and flexible optoelectronic device-based wearable pulse oximetry. Most previous studies have used OLEDs for this purpose, but did not consider the side effects of broad full-width half-maximum (FWHM) characteristics and single substrates. In this study, we performed SpO measurement using a fiber-based quantum-dot pulse oximetry (FQPO) system capable of mass production with a transferable encapsulation technique, and a narrow FWHM of about 30 nm. Based on analyses we determined that uniform angular narrow FWHM-based light sources are important for accurate SpO measurements through multi-layer structures and human skin tissues. The FQPO was shown to have improved photoplethysmogram (PPG) signal sensitivity with no waveguide-mode noise signal, as is typically generated when using a single substrate (30-50%). We successfully demonstrate improved SpO measurement accuracy as well as all-in-one clothing-type pulse oximetry with FQPO.
对实时医疗监测的需求不断增加，正推动基于薄型和柔性光电器件的可穿戴脉搏血氧仪取得进展。此前大多数研究为此使用了有机发光二极管（OLED），但未考虑宽半高全宽（FWHM）特性和单一基板的副作用。在本研究中，我们使用基于光纤的量子点脉搏血氧仪（FQPO）系统进行了血氧饱和度（SpO）测量，该系统采用可转移封装技术，能够进行大规模生产，并且半高全宽约为30纳米，较窄。基于分析，我们确定基于均匀角向窄半高全宽的光源对于通过多层结构和人体皮肤组织进行准确的SpO测量很重要。结果表明，FQPO具有更高的光电容积脉搏波描记图（PPG）信号灵敏度，且没有使用单一基板时通常会产生的波导模式噪声信号（30%-50%）。我们成功展示了使用FQPO提高的SpO测量精度以及一体式服装型脉搏血氧仪。
