Chabon A B, Stenger R J, Grabstald H
Urology. 1987 Jun;29(6):658-63. doi: 10.1016/0090-4295(87)90118-x.
Histologic sections from the testes of 32 autopsied patients with acquired immune deficiency syndrome (AIDS) were examined. Almost invariably the testes displayed decreased spermatogenesis, and 20 of the 32 cases showed marked hypospermatogenesis with Sertoli cells predominantly lining the tubules. Although the seminiferous tubules were generally of normal size, the tunica propria at the periphery of the tubules was mildly to moderately thickened in 19 cases and markedly thickened in 10. The interstitial cells of Leydig were unaltered in most patients, with only 4 testes showing Leydig cell hyperplasia. The testicular blood vessels were slightly thickened in many patients, but 5 exhibited moderate to marked intimal proliferation with narrowing of the lumen. Mononuclear inflammatory infiltration of the testicular interstitium was slight in 11 cases, moderate in 6. Only 7 of the 28 AIDS patients with opportunistic infections had evidence of direct involvement of the testes by the infectious organisms. We concluded that the extragonadal endocrine balance of AIDS patients may be deranged due to the infectious process and so deserves clinical evaluation.
对32例获得性免疫缺陷综合征（AIDS）尸检患者的睾丸组织切片进行了检查。几乎无一例外，睾丸显示精子发生减少，32例中有20例显示明显的精子发生减少，曲细精管主要由支持细胞内衬。尽管曲细精管通常大小正常，但19例曲细精管周围的固有膜轻度至中度增厚，10例明显增厚。大多数患者的睾丸间质细胞未改变，只有4个睾丸显示间质细胞增生。许多患者的睾丸血管轻度增厚，但5例表现为中度至明显的内膜增生，管腔狭窄。11例患者睾丸间质单核细胞炎性浸润轻微，6例中度。28例患有机会性感染的AIDS患者中，只有7例有感染病原体直接累及睾丸的证据。我们得出结论，AIDS患者的性腺外内分泌平衡可能因感染过程而紊乱，因此值得临床评估。
