人类免疫缺陷病毒/获得性免疫缺陷综合征与不孕：高效抗逆转录病毒治疗时代的新问题。
Human immunodeficiency virus/acquired immunodeficiency syndrome and infertility: emerging problems in the era of highly active antiretrovirals.
机构信息
Department of Gynecology and Obstetrics, Emory University, Atlanta, Georgia 30312, USA.
出版信息
Fertil Steril. 2011 Sep;96(3):546-53. doi: 10.1016/j.fertnstert.2011.05.094. Epub 2011 Jun 30.
Abstract
OBJECTIVE
To review the effects of human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) in terms of its associated comorbid conditions and the side effects of antiretroviral treatment on fertility.
DESIGN
PubMed computer search to identify relevant articles.
SETTING
Research institution.
PATIENT(S): None.
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): None.
RESULT(S): Biological alterations in reproductive physiology may account for subfertility in patients infected with HIV. Psychosocial factors in patients with HIV infection may affect their reproductive desires and outcomes. Antiretroviral medications may have direct toxicity on gametes and embryos. Available evidence indicates that fertility treatments can be a safe option for couples with HIV-discordant infection status, although the potential risk of viral transmission cannot be completely eliminated.
CONCLUSION(S): Because their potential reproductive desires are increasingly becoming a concern in the health care of young HIV-infected patients, additional data are needed to address the effect of HIV and its treatments on their fertility and reproductive outcomes.
摘要
目的
综述人类免疫缺陷病毒/获得性免疫缺陷综合征（HIV/AIDS）相关合并症及其对生育的影响，以及抗逆转录病毒治疗的副作用。
设计
利用 PubMed 计算机检索，以确定相关文章。
地点
研究机构。
患者
无。
干预措施
无。
主要观察指标
无。
结果
生殖生理学的生物学改变可能导致 HIV 感染患者的生育能力下降。HIV 感染者的心理社会因素可能会影响他们的生育愿望和结果。抗逆转录病毒药物可能对配子和胚胎有直接毒性。现有证据表明，对于 HIV 不一致感染状态的夫妇来说，生育治疗是一种安全的选择，尽管不能完全消除病毒传播的潜在风险。
结论
由于他们潜在的生育愿望越来越成为年轻 HIV 感染患者医疗保健的关注点，因此需要更多的数据来解决 HIV 及其治疗对其生育能力和生殖结果的影响。
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本文引用的文献
1
Sexually transmitted diseases treatment guidelines, 2010.性传播疾病治疗指南，2010 年。
MMWR Recomm Rep. 2010 Dec 17;59(RR-12):1-110.
2
Preexposure chemoprophylaxis for HIV prevention in men who have sex with men.男男性行为人群 HIV 预防的暴露前药物预防。
N Engl J Med. 2010 Dec 30;363(27):2587-99. doi: 10.1056/NEJMoa1011205. Epub 2010 Nov 23.
3
A decade of the sperm-washing programme: correlation between markers of HIV and seminal parameters.十年精子洗涤计划：HIV 标志物与精液参数的相关性。
HIV Med. 2011 Apr;12(4):195-201. doi: 10.1111/j.1468-1293.2010.00868.x. Epub 2010 Aug 18.
4
Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women.替诺福韦凝胶作为一种抗逆转录病毒的杀微生物剂，用于预防女性感染艾滋病毒的有效性和安全性。
Science. 2010 Sep 3;329(5996):1168-74. doi: 10.1126/science.1193748. Epub 2010 Jul 19.
5
Voluntary pregnancy termination among women with HIV in the HAART era (2002-2008): a case series from a national study.高效抗逆转录病毒治疗时代（2002 - 2008年）感染艾滋病毒女性的自愿终止妊娠：一项全国性研究的病例系列
AIDS Care. 2010 Jan;22(1):50-3. doi: 10.1080/09540120903033268.
6
Maternal mortality for 181 countries, 1980-2008: a systematic analysis of progress towards Millennium Development Goal 5.181 个国家孕产妇死亡率，1980-2008 年：迈向千年发展目标 5 的进展情况系统分析。
Lancet. 2010 May 8;375(9726):1609-23. doi: 10.1016/S0140-6736(10)60518-1. Epub 2010 Apr 9.
7
Human immunodeficiency virus and infertility treatment.人类免疫缺陷病毒与不孕治疗。
Fertil Steril. 2010 Jun;94(1):11-5. doi: 10.1016/j.fertnstert.2010.01.077. Epub 2010 Mar 16.
8
Impact of antiretroviral therapy on incidence of pregnancy among HIV-infected women in Sub-Saharan Africa: a cohort study.抗逆转录病毒疗法对撒哈拉以南非洲地区感染艾滋病毒的妇女妊娠发生率的影响：一项队列研究。
PLoS Med. 2010 Feb 9;7(2):e1000229. doi: 10.1371/journal.pmed.1000229.
9
Decrease of mitochondrial DNA level in sperm from patients infected with human immunodeficiency virus-1 linked to nucleoside analogue reverse transcriptase inhibitors.精子中线粒体 DNA 水平降低与感染人类免疫缺陷病毒-1 的患者中核苷类似物逆转录酶抑制剂有关。
Fertil Steril. 2010 Nov;94(6):2151-6. doi: 10.1016/j.fertnstert.2009.12.080. Epub 2010 Feb 13.
10
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Reprod Biomed Online. 2009 Aug;19(2):257-63. doi: 10.1016/s1472-6483(10)60082-x.
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